Evidence map›Paper›PMID 24954224›Full record

ReviewCellular & molecular immunology2014

Liaison between natural killer cells and dendritic cells in human gestation.

Ester Leno-Durán, Raquel Muñoz-Fernández, Enrique García Olivares, Irene Tirado-González

Open access · bronzeAbstract readReview
In one paragraph

Review in Cellular & molecular immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 47 citations in OpenAlex.

  1. Pathogenesis of viral infections during pregnancy.Clinical microbiology reviews · 2024
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Single-cell technologies in reproductive immunology.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. CMI: Highlights in last three years.Cellular & molecular immunology · 2016
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ester Leno-DuránInstituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain.
Raquel Muñoz-FernándezInstituto de Parasitología y Biomedicina 'López Neyra', Centro superior de investigaciones científicas, Armilla, Granada, Spain.
Enrique García Olivares1] Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain [2] Hospital Universitario San Cecilio, Granada, Spain.
Irene Tirado-González1] Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Armilla, Granada, Spain [2] Medicine University of Berlin, Charité Centre 12 Internal Medicine and Dermatology, Berlin, Germany.
Universidad de Granada · ESInstituto de Parasitología y Biomedicina "López - Neyra" · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN(+) dendritic cells (DCs) and CD56(+) natural killer (NK) cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.

Indexed as

CD56 AntigenCell Adhesion MoleculesCell CommunicationDC-Specific ICAM-3 Grabbing NonintegrinDendritic CellsFemaleHumansImmune ToleranceKiller Cells, NaturalLectins, C-TypePregnancyReceptors, Cell SurfaceUterusCD56 AntigenCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeReceptors, Cell Surface

Identifiers

PMID24954224
PMCPMC4197206
OpenAlexW2069696799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.