ArticleBiochimica et biophysica acta2014
An interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 98 citations in OpenAlex.
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- Hypothalamus Transcriptome Reveals Key lncRNAs and mRNAs Associated with Fecundity in Goats.Animals : an open access journal from MDPI · 2025Article
- The Response of the miRNA Profiles of the Thyroid Gland to the Artificial Photoperiod in Ovariectomized and Estradiol-Treated Ewes.Animals : an open access journal from MDPI · 2024Article
- Identification of Genes and Long Non-Coding RNAs Putatively Related toInternational journal of molecular sciences · 2024Article
- Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum.PLoS pathogens · 2024Article
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2023Article
- Overview of Avian Sex Reversal.International journal of molecular sciences · 2023Review
- Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023Review
- Transcriptome analysis reveals mRNAs and long non-coding RNAs associated with fecundity in the hypothalamus of high-and low-fecundity goat.Frontiers in veterinary science · 2023Article
- Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development.Molecular cell · 2022Article
- LncRNA-Chromatin Pull-Down Using Biotin-Conjugated DNA Probes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The long non-coding RNA rhabdomyosarcoma 2-associated transcript exerts anti-tumor effects on lung adenocarcinoma via ubiquitination ofAnnals of translational medicine · 2022Article
- Article
- Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars.Animals : an open access journal from MDPI · 2021Article
- Long Non-Coding RNAs in Insects.Animals : an open access journal from MDPI · 2021Review
- RNA-Seq Implies Divergent Regulation Patterns of LincRNA on Spermatogenesis and Testis Growth in Goats.Animals : an open access journal from MDPI · 2021Article
- Review
- Pineal gland transcriptomic profiling reveals the differential regulation of lncRNA and mRNA related to prolificacy in STH sheep with two FecB genotypes.BMC genomic data · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
Genome analysis in several eukaryotes shows a surprising number of transcripts which do not encode conventional messenger RNAs. Once considered noise, these non-coding RNAs (ncRNAs) appear capable of controlling gene expression by various means. We find that Drosophila sex determination, specifically the master-switch gene Sex-lethal (Sxl), is regulated by long ncRNAs (>200nt). The lncRNAs influence the dose sensitive establishment promoter of Sxl, SxlPe, which must be activated to specify female sex. They are primarily from two regions, R1 and R2, upstream of SxlPe and show a dynamic developmental profile. Of the four lncRNA strands only one, R2 antisense, has its peak coincident with SxlPe transcription, suggesting that it may promote activation. Indeed, its expression is regulated by the X chromosome counting genes, whose dose determines whether SxlPe is transcribed. Transgenic lines which ectopically express each of the lncRNAs show they can act in trans, not only impacting the process of sex determination but also altering the levels of the other lncRNAs. Generally, expression of R1 is negative whereas R2 is positive to females. This ectopic expression also results in a change in the local chromatin marks, affecting the timing and strength of SxlPe transcription. The chromatin marks are those deposited by the Polycomb and trithorax groups of chromatin modifying proteins, which we find bind to the lncRNAs. We suggest that the increasing numbers of non-coding transcripts being identified are a harbinger of interacting networks similar to the one we describe.
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