ArticleDevelopmental biology2014
The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation.PloS one · 2026Article
- VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans.PLoS genetics · 2025Article
- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- Maternal effects on postembryonic neuroblast migration in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Nervous system-wide analysis of allScience advances · 2025Article
- Consensus furin cleavage sites in the cuticular collagens DPY-17 and SQT-3 are required for Q neuroblast left-right asymmetric migration inmicroPublication biology · 2025Article
- MAB-5/Hox regulates the Q neuroblast transcriptome, including cwn-1/Wnt, to mediate posterior migration in Caenorhabditis elegans.Genetics · 2024Article
- The DPY-14 cuticle collagen regulates left-right asymmetric neuronal migration inmicroPublication biology · 2024Article
- MAB-5/Hox regulates the Q neuroblast transcriptome, includingbioRxiv : the preprint server for biology · 2023Article
- Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.Cell reports · 2022Article
- Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration.BMC genomics · 2022Article
- The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.PLoS genetics · 2021Article
- The Collagens DPY-17 and SQT-3 Direct Anterior-Posterior Migration of the Q Neuroblasts inJournal of developmental biology · 2021Article
- The Predicted RNA-Binding Protein ETR-1/CELF1 Acts in Muscles To Regulate Neuroblast Migration inG3 (Bethesda, Md.) · 2020Article
- Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts.Development (Cambridge, England) · 2019Article
- RHO-1 and the Rho GEF RHGF-1 interact with UNC-6/Netrin signaling to regulate growth cone protrusion and microtubule organization in Caenorhabditis elegans.PLoS genetics · 2019Article
- Fat-like cadherins in cell migration-leading from both the front and the back.Current opinion in cell biology · 2017Review
- Configuring a robust nervous system with Fat cadherins.Seminars in cell & developmental biology · 2017Review
- Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.Developmental cell · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Directed migration of neurons is critical in the normal and pathological development of the brain and central nervous system. In Caenorhabditis elegans, the bilateral Q neuroblasts, QR on the right and QL on the left, migrate anteriorly and posteriorly, respectively. Initial protrusion and migration of the Q neuroblasts is autonomously controlled by the transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21. As QL migrates posteriorly, it encounters and EGL-20/Wnt signal that induces MAB-5/Hox expression that drives QL descendant posterior migration. QR migrates anteriorly away from EGL-20/Wnt and does not activate MAB-5/Hox, resulting in anterior QR descendant migration. A forward genetic screen for new mutations affecting initial Q migrations identified alleles of cdh-4, which caused defects in both QL and QR directional migration similar to unc-40, ptp-3, and mig-21. Previous studies showed that in QL, PTP-3/LAR and MIG-21 act in a pathway in parallel to UNC-40/DCC to drive posterior QL migration. Here we show genetic evidence that CDH-4 acts in the PTP-3/MIG-21 pathway in parallel to UNC-40/DCC to direct posterior QL migration. In QR, the PTP-3/MIG-21 and UNC-40/DCC pathways mutually inhibit each other, allowing anterior QR migration. We report here that CDH-4 acts in both the PTP-3/MIG-21 and UNC-40/DCC pathways in mutual inhibition in QR, and that CDH-4 acts cell-non-autonomously. Interaction of CDH-4 with UNC-40/DCC in QR but not QL represents an inherent left-right asymmetry in the Q cells, the nature of which is not understood. We conclude that CDH-4 might act as a permissive signal for each Q neuroblast to respond differently to anterior-posterior guidance information based upon inherent left-right asymmetries in the Q neuroblasts.
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Registered trials
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