Evidence map›Paper›PMID 24953982›Full record

ArticleThrombosis research2014

Risk factors for hospital-sssociated venous thromboembolism in the neonatal intensive care unit.

Ernest K Amankwah, Christie M Atchison, Shilpa Arlikar, Irmel Ayala, Laurie Barrett, Brian R Branchford, Michael Streiff, Clifford Takemoto, Neil A Goldenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Hospital-Acquired Venous Thromboembolism Among Children With Tracheostomy: A North American Virtual Pediatric Systems Registry Study, 2016-2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Article
  7. Article
  8. Article
  9. The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Venous thrombosis in neonates.Faculty reviews · 2021
    Review
  17. Article
  18. Observational
  19. Treatment and follow-up of venous thrombosis in the neonatal intensive care unit: a retrospective study.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Article
  20. Neonatal Venous Thromboembolism.Frontiers in pediatrics · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Ernest K AmankwahClinical and Translational Research Organization, All Children's Research Institute, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, FL, USA.
Christie M AtchisonUndergraduate Medical Education, Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Shilpa ArlikarClinical and Translational Research Organization, All Children's Research Institute, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, FL, USA.
Irmel AyalaJohns Hopkins Medicine Pediatric Thrombosis Program, All Children's Hospital and Johns Hopkins Children's Center, St. Petersburg, FL and Baltimore, MD, USA.
Laurie BarrettClinical and Translational Research Organization, All Children's Research Institute, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, FL, USA; Johns Hopkins Medicine Pediatric Thrombosis Program, All Children's Hospital and Johns Hopkins Children's Center, St. Petersburg, FL and Baltimore, MD, USA.
Brian R BranchfordSection of Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, University of Colorado School of Medicine Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, USA.
Michael StreiffDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clifford TakemotoJohns Hopkins Medicine Pediatric Thrombosis Program, All Children's Hospital and Johns Hopkins Children's Center, St. Petersburg, FL and Baltimore, MD, USA; Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neil A GoldenbergClinical and Translational Research Organization, All Children's Research Institute, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, FL, USA; Johns Hopkins Medicine Pediatric Thrombosis Program, All Children's Hospital and Johns Hopkins Children's Center, St. Petersburg, FL and Baltimore, MD, USA; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: neil.goldenberg@allkids.org.
Johns Hopkins University · USChildren's Hospital Colorado · USJohns Hopkins All Children's Hospital · USJohns Hopkins Children's Center · USJohns Hopkins Medicine · USUniversity of South Florida · US

Funding

Clinical Investigation in Pediatric ThrombosisK23HL084055 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GOLDENBERG, NEIL A · 2007 to 2011
$743k
NHLBI NIH HHS K23 HL084055
6 · The paper itself

Abstract

objectiveTo determine hospital-associated venous thromboembolism (HA-VTE) risk factors in critically ill neonates.

methodsWe conducted a case-control study in the neonatal intensive care unit (NICU) of All Children's Hospital Johns Hopkins Medicine (St. Petersburg, FL), from January 1, 2006 - April 10, 2013. We identified HA-VTE cases using electronic health record. Four NICU controls were randomly selected for each HA-VTE case. Associations between putative risk factors and HA-VTE were estimated using odds ratios (ORs) and ninety-five percent confidence intervals (95%CIs) from univariate and multivariate regression analyses.

resultsTwenty-three HA-VTE cases and 92 controls were included. The annual HA-VTE incidence was approximately 1.4 HA-VTE cases per 1,000 NICU admissions. In univariate analyses, mechanical ventilation (OR=7.27, 95%CI=2.02-26.17, P=0.002), central venous catheter (CVC; OR=52.95, 95%CI=6.80-412.71, P<0.001), infection (OR=7.24, 95%CI=2.66-19.72, P<0.001), major surgery (OR=5.60, 95%CI=1.82-17.22, P=0.003) and length of stay ≥15days (OR=6.67, 95%CI=1.85-23.99, P=0.004) were associated with HA-VTE. Only CVC (OR=29.04, 95%CI=3.18-265.26, P=0.003) remained an independent risk factor in the multivariate analysis. Based on this result, the estimated risk of HA-VTE in NICU patients with a CVC was 0.9%.

conclusionThis study identifies CVC as an independent risk factor for HA-VTE in critically ill neonates. However, the level of risk associated with CVC is below the conventional threshold for primary anticoagulation thromboprophylaxis. Larger studies are needed to substantiate these findings and identify novel putative risk factors to further distinguish NICU patients at highest HA-VTE risk.

Indexed as

Case-Control StudiesCentral Venous CathetersCritical IllnessFemaleHumansIncidenceInfantInfant, NewbornInfectionsIntensive Care Units, NeonatalMaleOdds RatioPostoperative ComplicationsRespiration, ArtificialRisk FactorsVenous Thromboembolismneonatesrisk factorthrombosisvenous thromboembolism

Identifiers

PMID24953982
PMCPMC7269108
OpenAlexW1971784156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.