Evidence map›Paper›PMID 24953895›Full record

Observational studyJournal of vascular surgery2014

Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease.

Emily V Nosova, Karen C Chong, Hugh F Alley, William S Harris, W John Boscardin, Michael S Conte, Christopher D Owens, S Marlene Grenon

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Smoking and red blood cell phospholipid membrane fatty acids.Prostaglandins, leukotrienes, and essential fatty acids · 2016
    Article
  5. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Emily V NosovaDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, Calif.
Karen C ChongDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, Calif.
Hugh F AlleyDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, Calif.
William S HarrisDepartment of Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SDak; Health Diagnostic Laboratory, Inc, Richmond, Va.
W John BoscardinDepartments of Medicine and of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, Calif.
Michael S ConteDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, Calif.
Christopher D OwensDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, Calif; Department of Surgery, Veterans Affairs Medical Center, San Francisco, Calif.
S Marlene GrenonDepartment of Surgery, University of California, San Francisco, San Francisco, Calif; VIPERx Laboratory, San Francisco, Calif; Department of Surgery, Veterans Affairs Medical Center, San Francisco, Calif. Electronic address: marlene.grenon@ucsfmedctr.org.
University of California, San Francisco · USSan Francisco VA Medical Center · USSanford Health · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Effects of fish oil on inflammation and vascular function in claudicantsK23HL122446 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRENON, MARLENE · 2014 to 2017
$806k
NCATS NIH HHS KL2 TR000143NCRR NIH HHS KL2 RR024130NCRR NIH HHS KL2RR024130NHLBI NIH HHS K23 HL122446NIA NIH HHS P30 AG044281
6 · The paper itself

Abstract

objectiveDespite available medical therapies, patients with peripheral arterial disease (PAD) remain at high risk for cardiovascular events. The n-3 polyunsaturated fatty acids (PUFA), derived from marine sources, have been shown to improve cardiovascular mortality. The Omega-3 Index (O3I), a proportion of the n-3 PUFA eicosapentaenoic acid and docosahexaenoic acid in the red blood cell membrane, correlates with cardiovascular risk. Previous investigations have found that n-3 PUFA supplementation, fish consumption, older age, and smoking history affect the O3I in different patient populations, although similar correlations have never been explored in PAD. We hypothesized that in our PAD cohort, blood content of omega-3 fatty acids would directly and positively correlate with a history of fish oil supplementation and older age and inversely correlate with a smoking history and obesity.

methodsThis cross-sectional study included 111 patients who had an ankle-brachial index of <0.9 associated with claudication symptoms. We used linear regression to determine the association between clinical factors and the O3I.

resultsThe mean age of the cohort was 69 ± 8 years; 37% had diabetes mellitus (hemoglobin A1c, 7% ± 1%), and 94% reported current smoking or a history of smoking. The mean O3I was 5% ± 2%. In multivariate linear regression analysis, the O3I was associated with older age, increasing body mass index, and a history of smoking and fish oil intake.

conclusionsThis is the first report of the relation between blood content of omega-3 fatty acids and clinical factors in a PAD population. In patients with PAD, older age, elevated body mass index, and prior fish oil supplementation predicted a higher O3I. A history of smoking correlated with a lower O3I. These results demonstrate that the O3I is a reliable measure of dietary n-3 PUFA intake and that clinical factors related to the O3I in PAD are similar to those observed in other populations.

Indexed as

Veterans HealthAgedAge FactorsAnkle Brachial IndexBiomarkersBody Mass IndexChi-Square DistributionCross-Sectional StudiesDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidErythrocyte MembraneFemaleHumansLinear ModelsMaleBiomarkersDocosahexaenoic AcidsEicosapentaenoic Acid

Identifiers

PMID24953895
PMCPMC4253902
OpenAlexW1967327173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.