Evidence map›Paper›PMID 24953189›Full record

ArticleBiochimica et biophysica acta2014

A TEAD1/p65 complex regulates the eutherian-conserved MnSOD intronic enhancer, eRNA transcription and the innate immune response.

Ann L Chokas, Justin S Bickford, Sarah J Barilovits, Richard J Rogers, Xiaolei Qiu, Kimberly J Newsom, Dawn E Beachy, Harry S Nick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Targeting TEAD in cancer.Frontiers in oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ann L ChokasDepartments of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Justin S BickfordDepartments of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Sarah J BarilovitsBiochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Richard J RogersBiochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Anesthesiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Xiaolei QiuBiochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kimberly J NewsomDepartments of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Dawn E BeachyDepartments of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Harry S NickDepartments of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: hnick@ufl.edu.
University of Florida · US

Funding

Regulation Of Cytosolic Phospholipase A2 In The LungR37HL067456 · NHLBI · UNIVERSITY OF FLORIDA · PI NICK, HARRY S · 2002 to 2010
$3.1M
REGULATION OF SUPEROXIDE DISMUTASES IN THE LUNGR01HL039593 · NHLBI · UNIVERSITY OF FLORIDA · PI NICK, HARRY S · 1987 to 2006
$2.1M
NHLBI NIH HHS R01 HL039593NHLBI NIH HHS R01HL39593NHLBI NIH HHS R37 HL067456NHLBI NIH HHS R37HL067456
6 · The paper itself

Abstract

Manganese superoxide dismutase (MnSOD), a critical anti-oxidant enzyme, detoxifies the mitochondrial-derived reactive oxygen species, superoxide, elicited through normal respiration or the inflammatory response. Proinflammatory stimuli induce MnSOD gene expression through a eutherian-conserved, intronic enhancer element. We identified two prototypic enhancer binding proteins, TEAD1 and p65, that when co-expressed induce MnSOD expression comparable to pro-inflammatory stimuli. TEAD1 causes the nuclear sequestration of p65 leading to a novel TEAD1/p65 complex that associates with the intronic enhancer and is necessary for cytokine induction of MnSOD. Unlike typical NF-κB-responsive genes, the induction of MnSOD does not involve p50. Beyond MnSOD, the TEAD1/p65 complex regulates a subset of genes controlling the innate immune response that were previously viewed as solely NF-κB-dependent. We also identified an enhancer-derived RNA (eRNA) that is induced by either proinflammatory stimuli or the TEAD1/p65 complex, potentially linking the intronic enhancer to intra- and interchromosomal gene regulation through the inducible eRNA.

Indexed as

Gene Expression RegulationAnimalsBase SequenceCells, CulturedDNA-Binding ProteinsEnhancer Elements, GeneticHumansImmunity, InnateIntronsMolecular Sequence DataNuclear ProteinsProtein BindingRatsRNASuperoxide DismutaseTEA Domain Transcription FactorsDNA-Binding ProteinsNuclear ProteinsRNASuperoxide DismutaseTEAD1 protein, humanTEA Domain Transcription FactorsTranscription Factor RelATranscription FactorsEnhancer-derived RNA (eRNA)Intronic enhancerManganese superoxide dismutase (MnSOD)p65TEAD1

Identifiers

PMID24953189
PMCPMC4252815
OpenAlexW2007057830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.