Evidence map›Paper›PMID 24953182›Full record

ArticleCell stem cell2014

Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling.

Manash K Paul, Bharti Bisht, Daphne O Darmawan, Richard Chiou, Vi L Ha, William D Wallace, Andrew T Chon, Ahmed E Hegab, Tristan Grogan, David A Elashoff and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 287 citations in OpenAlex.

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  6. Antioxidant Synergy ofACS omega · 2026
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Manash K PaulDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bharti BishtDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Daphne O DarmawanDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Richard ChiouDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Vi L HaDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
William D WallaceDepartment of Pathology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrew T ChonDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ahmed E HegabDivision of Pulmonary Medicine, Department of Medicine, Keio University Medical School, Tokyo 160-8582, Japan.
Tristan GroganDepartment of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David A ElashoffDepartment of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Pulmonary Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jackelyn A Alva-OrnelasDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brigitte N GompertsDepartment of Pediatrics, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA; Pulmonary Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: bgomperts@mednet.ucla.edu.
University of California, Los Angeles · USKeio University · JPMattel Children's Hospital · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Progenitor Cells in Airway RepairR01HL094561 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMPERTS, BRIGITTE N · 2009 to 2013
$1.9M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS P30 CA016042NHLBI NIH HHS HL094561NHLBI NIH HHS R01 HL094561
6 · The paper itself

Abstract

Airways are exposed to myriad environmental and damaging agents such as reactive oxygen species (ROS), which also have physiological roles as signaling molecules that regulate stem cell function. However, the functional significance of both steady and dynamically changing ROS levels in different stem cell populations, as well as downstream mechanisms that integrate ROS sensing into decisions regarding stem cell homeostasis, are unclear. Here, we show in mouse and human airway basal stem cells (ABSCs) that intracellular flux from low to moderate ROS levels is required for stem cell self-renewal and proliferation. Changing ROS levels activate Nrf2, which activates the Notch pathway to stimulate ABSC self-renewal and an antioxidant program that scavenges intracellular ROS, returning overall ROS levels to a low state to maintain homeostatic balance. This redox-mediated regulation of lung stem cell function has significant implications for stem cell biology, repair of lung injuries, and diseases such as cancer.

Indexed as

AnimalsAntioxidantsCell CycleCell DifferentiationCell ProliferationHomeostasisHumansMiceNF-E2-Related Factor 2Oxidation-ReductionPolidocanolPolyethylene GlycolsReactive Oxygen SpeciesReceptors, NotchSignal TransductionStem CellsAntioxidantsNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2PolidocanolPolyethylene GlycolsReactive Oxygen SpeciesReceptors, Notch

Identifiers

PMID24953182
PMCPMC4127166
OpenAlexW1979803626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.