Evidence map›Paper›PMID 24952993›Full record

ReviewNeurobiology of aging2014

Physical activity, fitness, and gray matter volume.

Kirk I Erickson, Regina L Leckie, Andrea M Weinstein

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 304 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04138563 unknown statusnot on this mapstarted 2019, after this paper: background citation

Cardiac Output and Brain Perfusion and Architecture During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Healthy, Age Matched Volunteers

TypeobservationalSponsorUniversity of NottinghamRan2019 to 2020Enrolled30ConditionsCOPD, Cognitive Impairment
NCT06376656 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Successful Ageing: Evidence-based Interventions to Delay Ageing-related Decline

TypeinterventionalSponsorSunway UniversityRan2022 to 2030Enrolled400ConditionsAging, Elderly, Cognitive Decline, Physical DeclineArmsCognitive stimulation, Physical activity
3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kirk I EricksonDepartment of Psychology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: kiericks@pitt.edu.
Regina L LeckieDepartment of Psychology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Andrea M WeinsteinDepartment of Psychology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
NIDDK NIH HHS R01 DK095172
6 · The paper itself

Abstract

In this review, we explore the association among physical activity, cardiorespiratory fitness, and exercise on gray matter volume in older adults. We conclude that higher cardiorespiratory fitness levels are routinely associated with greater gray matter volume in the prefrontal cortex and hippocampus and less consistently in other regions. We also conclude that physical activity is associated with greater gray matter volume in the same regions that are associated with cardiorespiratory fitness including the prefrontal cortex and hippocampus. Some heterogeneity in the literature may be explained by effect moderation by age, stress, or other factors. Finally, we report promising results from randomized exercise interventions that suggest that the volume of the hippocampus and prefrontal cortex remain pliable and responsive to moderate intensity exercise for 6 months-1 year. Physical activity appears to be a propitious method for influencing gray matter volume in late adulthood, but additional well-controlled studies are necessary to inform public policies about the potential protective or therapeutic effects of exercise on brain volume.

Indexed as

AgedAged, 80 and overAgingCross-Sectional StudiesExerciseGray MatterHippocampusHumansMeta-Analysis as TopicMiddle AgedMotor ActivityOrgan SizePhysical FitnessPrefrontal CortexRandomized Controlled Trials as TopicAgingCognitionExerciseGray matter volumePhysical activity

Identifiers

PMID24952993
PMCPMC4094356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.