Trial reportThe Journal of pediatrics2014
Factors associated with neurodevelopment for children with single ventricle lesions.
Trial report in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Growth and risk of adverse neuro-developmental outcome in infants with congenital heart disease: A systematic review.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- Developmental outcomes after early surgery for complex congenital heart disease: a systematic review and meta-analysis.Developmental medicine and child neurology · 2021Pooled it
- Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network's Single Ventricle Reconstruction Trial.Circulation · 2025Trial
- Trial
- Nasal Nitric Oxide as a Novel Biomarker for Assessing Risk of Impaired Neurodevelopment in Infants and Newborns with Congenital Heart Disease.Pediatric cardiology · 2026Article
- Executive Functioning in Kindergarten-Aged Children After Complex Cardiac Surgery in Early Infancy.CJC pediatric and congenital heart disease · 2026Article
- Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease.JAMA network open · 2026Article
- Assessment of Early Development in Congenital Heart Disease Using a Novel Caregiver Rating Method.Pediatric cardiology · 2026Article
- Early Neurodevelopmental Outcomes in Patients Who Undergo Hybrid Stage I Palliation Compared to Norwood Stage I Palliation for Hypoplastic Left Heart Syndrome.Pediatric cardiology · 2026Article
- Article
- Unique model of chronic hypoxia in fetal lambs demonstrates abnormal contrast-enhanced ultrasound brain perfusion.Pediatric research · 2025Article
- Family Socioeconomic Status and Neurodevelopment Among Patients With Dextro-Transposition of the Great Arteries.JAMA network open · 2024Article
- Trends in Gaps of Care for Patients With Congenital Heart Disease: Implications for Social Determinants of Health and Child Opportunity Index.Journal of the American Heart Association · 2024Article
- Social Determinants of Health Including Child Opportunity Index Leading to Gaps in Care for Patients With Significant Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Neurodevelopment in patients with repaired tetralogy of Fallot.Frontiers in pediatrics · 2024Review
- Research gaps in the neurodevelopmental assessment of children with complex congenital heart defects: a scoping review.Frontiers in pediatrics · 2024Article
- E-Health: A Game Changer in Fetal and Neonatal Cardiology?Journal of clinical medicine · 2023Review
- Five decades of Fontan palliation: What have we learned? What should we expect?The Journal of international medical research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
objectiveTo measure neurodevelopment at 3 years of age in children with single right-ventricle anomalies and to assess its relationship to Norwood shunt type, neurodevelopment at 14 months of age, and patient and medical factors. STUDY
designAll subjects in the Single Ventricle Reconstruction Trial who were alive without cardiac transplant were eligible for inclusion. The Ages and Stages Questionnaire (ASQ, n = 203) and other measures of behavior and quality of life were completed at age 3 years. Medical history, including measures of growth, feeding, and complications, was assessed through annual review of the records and phone interviews. The Bayley Scales of Infant Development, Second Edition (BSID-II) scores from age 14 months were also evaluated as predictors.
resultsScores on each ASQ domain were significantly lower than normal (P < .001). ASQ domain scores at 3 years of age varied nonlinearly with 14-month BSID-II. More complications, abnormal growth, and evidence of feeding, vision, or hearing problems were independently associated with lower ASQ scores, although models explained <30% of variation. Type of shunt was not associated with any ASQ domain score or with behavior or quality-of-life measures.
conclusionChildren with single right-ventricle anomalies have impaired neurodevelopment at 3 years of age. Lower ASQ scores are associated with medical morbidity, and lower BSID-II scores but not with shunt type. Because only a modest percentage of variation in 3-year neurodevelopmental outcome could be predicted from early measures, however, all children with single right-ventricle anomalies should be followed longitudinally to improve recognition of delays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.