Evidence map›Paper›PMID 24952205›Full record

ReviewInternational immunopharmacology2014

Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis.

Jonathan M Gaffin, Watcharoot Kanchongkittiphon, Wanda Phipatanakul

Abstract readReview
In one paragraph

Review in International immunopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018
    Review
  11. Review
  12. Modifiable risk factors associated with bronchiolitis.Therapeutic advances in respiratory disease · 2017
    Observational
  13. Article
  14. Health Issues in Hispanic/Latino Youth.Journal of Latina/o psychology · 2016
    Article
  15. Review
  16. It Starts at the Beginning: Effect of Particulate Matter In Utero.American journal of respiratory and critical care medicine · 2015
    Article
  17. Review
  18. Epigenetic contributions to the developmental origins of adult lung disease.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2015
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jonathan M GaffinDivision of Respiratory Diseases, Boston Children's Hospital, Boston, MA; USA; Harvard Medical School, Boston, MA, USA. Electronic address: jonathan.gaffin@childrens.harvard.edu.
Watcharoot KanchongkittiphonDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: champw@hotmail.com.
Wanda PhipatanakulHarvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Boston, MA, USA. Electronic address: wanda.phipatanakul@childrens.harvard.edu.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
AsthmaNet: Brigham and Women's Hospital & Children's Hospital BostonU10HL098102 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, PHIPATANAKUL, WANDA · 2009 to 2015
$5.5M
ALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6M
Midcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9M
School-based air pollution and asthma morbidity in Inner City School ChildrenK23AI106945 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2013 to 2017
$822k
NCATS NIH HHS UL1 TR001102NCRR NIH HHS UL1 RR 025758NCRR NIH HHS UL1 RR025758NHLBI NIH HHS U10 HL098102NHLBI NIH HHS U10HL098102NIAID NIH HHS K23 AI106945NIAID NIH HHS K23AI106945-01NIAID NIH HHS K24 AI 106822NIAID NIH HHS K24 AI106822NIAID NIH HHS R01 AI 073964NIAID NIH HHS R01 AI073964NIAID NIH HHS R01 AI 073964-02S1
6 · The paper itself

Abstract

backgroundThe prevalence of asthma has increased dramatically over the past several decades. While hereditary factors are highly important, the rapid rise outstrips the pace of genomic variation. Great emphasis has been placed on potential modifiable early life exposures leading to childhood asthma.

methodsWe reviewed the recent medical literature for important studies discussing the role of the perinatal and early childhood exposures and the inception of childhood asthma. RESULTS AND DISCUSSION: Early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO(2)), ozone (O(3)), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms.

Indexed as

Air PollutionAllergensEnvironmental ExposureAsthmaChildChild, PreschoolFemaleHumansInfantInfant, NewbornPerinatal CarePregnancyRiskVirus DiseasesAllergensAsthmaChildhood asthmaEnvironmental allergiesMicrobiome

Identifiers

PMID24952205
PMCPMC4119505

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.