Evidence map›Paper›PMID 24952187›Full record

ReviewAdvances in experimental medicine and biology2014

Mass spectrometry-based tissue imaging of small molecules.

Carly N Ferguson, Joseph W M Fowler, Jonathan F Waxer, Richard A Gatti, Joseph A Loo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Bringing SEM and MSI Closer Than Ever Before: VisualizingJournal of fungi (Basel, Switzerland) · 2020
    Article
  5. Article
  6. Article
  7. MeV-SIMS TOF Imaging of Organic Tissue with Continuous Primary Beam.Journal of the American Society for Mass Spectrometry · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carly N FergusonDepartment of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Joseph W M Fowler
Jonathan F Waxer
Richard A Gatti
Joseph A Loo
University of California, Los Angeles · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
MALDI TOF/TOF Mass Spectrometer for Imaging Thin Tissue SectionsS10RR025600 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOO, JOSEPH A · 2010 to 2010
$466k
NCRR NIH HHS S10 RR025600NCRR NIH HHS S10RR025600NIGMS NIH HHS GM007185NIGMS NIH HHS R25 GM055052NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

Mass spectrometry imaging (MSI) of tissue samples is a promising analytical tool that has quickly become associated with biomedical and pharmacokinetic studies. It eliminates several labor-intensive protocols associated with more classical imaging techniques and provides accurate histological data at a rapid pace. Because mass spectrometry is used as the readout, MSI can be applied to almost any molecule, especially those that are biologically relevant. Many examples of its utility in the study of peptides and proteins have been reported; here we discuss its value in the mass range of small molecules. We explore its success and potential in the analysis of lipids, medicinals, and metal-based compounds by featuring representative studies from MSI laboratories around the globe.

Indexed as

AnimalsHumansMass SpectrometryMolecular ImagingPeptidesProteinsPeptidesProteins

Identifiers

PMID24952187
PMCPMC4183127
OpenAlexW1438841840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.