ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2014
A non-digestible fraction of the common bean (Phaseolus vulgaris L.) induces cell cycle arrest and apoptosis during early carcinogenesis.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors.Nutrients · 2018Trial
- The Nutraceutical Promise ofBiology · 2026Review
- Antioxidant Activity and Resistance Against Oxidation of Peptide Fractions from Common Bean (Antioxidants (Basel, Switzerland) · 2026Article
- Potential Human Health Benefits ofNutrients · 2024Article
- In vitro Digestion ofFoods (Basel, Switzerland) · 2023Article
- Phaseolin, a Protein from the Seed ofNutrients · 2021Article
- Article
- Cooked Red Lentils Dose-Dependently Modulate the Colonic Microenvironment in Healthy C57Bl/6 Male Mice.Nutrients · 2019Article
- Inhibitory Effects of Pulse Bioactive Compounds on Cancer Development Pathways.Diseases (Basel, Switzerland) · 2018Review
- Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits.International journal of molecular sciences · 2017Review
- Characterization and Comparison of Protein and Peptide Profiles and their Biological Activities of Improved Common Bean Cultivars (Phaseolus vulgaris L.) from Mexico and Brazil.Plant foods for human nutrition (Dordrecht, Netherlands) · 2015Article
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Authors and funding
7 authors.
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Abstract
We have previously demonstrated that the non-digestible fraction (NDF) from common cooked beans (P. vulgaris L., cv Negro 8025) inhibits azoxymethane (AOM)-induced colon cancer and influences the expression of genes involved in the induction of apoptosis and cell cycle arrest through the action of butyrate. The objective of this study was to identify cell cycle alterations and morphological changes induced by treatment with AOM and to examine the formation of colonic aberrant crypt foci (ACF) in male Sprague Dawley rats fed with these beans. Rats were fed control diets upon arrival and were randomly placed into four groups after one week of acclimatization: control, NDF (intragastric administration), NDF + AOM and AOM. Rats treated with NDF + AOM exhibited a significantly lower number of total colonic ACF with a notable increase in the number of cells present in the G1 phase (83.14%); a decreased proliferation index was observed in the NDF + AOM group when compared to AOM group. NDF + AOM also displayed a higher number of apoptotic cells compared to AOM group. NDF of cooked common beans inhibited colon carcinogenesis at an early stage by inducing cell cycle arrest of colon cells and morphological changes linked to apoptosis, thus confirming previous results obtained with gene expression studies.
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