ArticleVaccine2014
Prevalence of chronic hepatitis B virus infection before and after implementation of a hepatitis B vaccination program among children in Nepal.
Article in Vaccine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis.BMC infectious diseases · 2017Pooled it
- Cancer Prevention Strategies for Nepal.JNMA; journal of the Nepal Medical Association · 2022Article
- Review
- Serological markers and molecular analysis of hepatitis B infection in a tertiary care hospital at Kathmandu, Nepal.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Evaluation of Four Rapid Tests for Detection of Hepatitis B Surface Antigen in Ivory Coast.Journal of immunology research · 2020Article
- Prevalence of hepatitis B surface antigen (HBsAg) positivity and its associated factors in Rwanda.BMC infectious diseases · 2019Article
- Status and progress of hepatitis B control through vaccination in the South-East Asia Region, 1992-2015.Vaccine · 2018Review
- Seroprevalence of hepatitis B and C in Nepal: a systematic review (1973-2017).Hepatology, medicine and policy · 2018Review
- Prevalence and risk factors of hepatitis B infection among mothers and children with hepatitis B infected mother in upper Dolpa, Nepal.BMC infectious diseases · 2017Article
- Hepatitis B vaccination in Nepalese infants: The present scenario.Nepal journal of epidemiology · 2017Article
- Occupational Hepatitis B Exposure: A Peek into Indian Dental Students' Knowledge, Opinion, and Preventive Practices.Interdisciplinary perspectives on infectious diseases · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundIn Nepal, an estimated 2-4% of the population has chronic hepatitis B virus (HBV) infection. To combat this problem, from 2002 to 2004, a national three dose hepatitis B vaccination program was implemented to decrease infection rates among children. The program does not currently include a birth dose to prevent perinatal HBV transmission. In 2012, to assess the impact of the program, we conducted a serosurvey among children born before and after vaccine introduction.
methodsIn 2012, a cross-sectional nationally representative stratified cluster survey was conducted to estimate hepatitis B surface antigen (HBsAg) prevalence among children born from 2006 to 2007 (post-vaccine cohort) and among children born from 2000 to 2002 (pre-vaccine cohort). Demographic data, as well as written and oral vaccination history were collected. All children were tested for HBsAg; mothers of HBsAg positive children were also tested. Furthermore, we evaluated the field sensitivity and specificity of the SD Bioline HBsAg rapid diagnostic test by comparing results with an enzyme immunoassay.
resultsAmong 2181 post-vaccination cohort children with vaccination data by either card or recall, 86% (95% confidence interval [CI] 77-95%) received ≥ 3 hepatitis B vaccine doses. Of 1200 children born in the pre-vaccination cohort, 0.28% (95% CI 0.09-0.85%) were positive for HBsAg; of 2187 children born in the post-vaccination cohort, 0.13% (95% CI 0.04-0.39%) were positive for HBsAg (p=0.39). Of the six children who tested positive for HBsAg, two had mothers who were positive for HBsAg. Finally, we found the SD Bioline HBsAg rapid diagnostic test to have a sensitivity of 100% and a specificity of 100%.
conclusionsThis is the first nationally representative hepatitis B serosurvey conducted in Nepal. Overall, a low burden of chronic HBV infection was found in children born in both the pre and post-vaccination cohorts. Current vaccination strategies should be continued.
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