ArticleThe Journal of infectious diseases2014
Superantigens of Staphylococcus aureus from patients with diabetic foot ulcers.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 37 citations in OpenAlex.
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- Multivalent nanobodies for potent and broad neutralization of Staphylococcus aureus toxins.Nature communications · 2026Article
- Observations on emergence of mannitol-use-deficientMicrobiology spectrum · 2026Article
- Risk Factors Associated With Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.mSphere · 2025Article
- Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.World journal of diabetes · 2025Article
- Whole genome sequencing and pan-genome analysis of Staphylococcus/Mammaliicoccus spp. isolated from diabetic foot ulcers and contralateral healthy skin of Algerian patients.BMC microbiology · 2023Article
- Enterotoxin Gene Cluster andCells · 2022Article
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- TSST-1The Journal of investigative dermatology · 2022Article
- Role of Glucose-6-Phosphate in Metabolic Adaptation of Staphylococcus aureus in Diabetes.Microbiology spectrum · 2021Article
- Investigation of Staphylococcus aureus positive for Staphylococcal enterotoxin S and T genes.The Journal of veterinary medical science · 2021Article
- Virulence factors and clonal diversity of Staphylococcus aureus in colonization and wound infection with emphasis on diabetic foot infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Human Keratinocyte Response to Superantigens.mSphere · 2020Article
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- High Prevalence ofGenes · 2019Article
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- Characterization of Human Type C Enterotoxin Produced by Clinical S. epidermidis Isolates.Toxins · 2018Article
- Microbial Diversity of Chronic Wound and Successful Management of Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Dying blood mononuclear cell secretome exerts antimicrobial activity.European journal of clinical investigation · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDiabetic foot ulcer (DFU) infections are challenging. Staphylococcus aureus is the most commonly isolated pathogen in DFUs. Superantigens (SAgs) are causative in many S. aureus infections. We hypothesized both that DFU S. aureus will produce large SAg numbers, consistent with skin infections, and that certain SAgs will be overrepresented. We assessed the SAg and α-toxin profile of isolates from patients with DFU, compared with profiles of isolates from other sources. MATERIALS: Twenty-five S. aureus isolates from patients with DFU were characterized. Polymerase chain reaction was used to detect genes for methicillin-resistance and SAgs. Some SAgs and the α-toxin were quantified. We compared the SAg profile of DFU isolates with SAg profiles of S. aureus isolates from skin lesions of patients with atopic dermatitis and from vaginal mucosa of healthy individuals.
resultsMost DFU isolates were methicillin susceptible (64%), with USA100 the most common clonal group. The SAg gene profile of DFU isolates most closely resembled that of isolates from patients with atopic dermatitis, with the highest number of different SAg genes per isolate and a high prevalence of staphylococcal enterotoxin D and the enterotoxin gene cluster. DFU isolates also had a high prevalence of staphylococcal enterotoxin-like X.
conclusionsComparison of the SAg profile of DFU isolates to SAg profiles of skin lesion isolates and vaginal mucosa isolates revealed that the SAg profile of DFU isolates was more similar to that of skin lesion isolates. SAgs offer selective advantages in facilitating DFU infections and suggest that therapies to neutralize or reduce SAg production by S. aureus may be beneficial in management of patients with DFU.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.