ArticleJournal of clinical microbiology2014
Whole-genome analysis of Exserohilum rostratum from an outbreak of fungal meningitis and other infections.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?Expert review of molecular diagnostics · 2024Review
- Cross-species transmission of a novel bisegmented orfanplasmovirus in the phytopathogenic fungusFrontiers in microbiology · 2024Article
- Outbreaks of Fungal Infections in Hospitals: Epidemiology, Detection, and Management.Journal of fungi (Basel, Switzerland) · 2023Review
- A Repertoire of Clinical Non-Dermatophytes Moulds.Journal of fungi (Basel, Switzerland) · 2023Review
- Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020.Medical mycology · 2023Article
- The Chromosome-Scale Genomes ofJournal of fungi (Basel, Switzerland) · 2023Article
- Comparative mitochondrial genome analyses reveal conserved gene arrangement but massive expansion/contraction in two closely relatedComputational and structural biotechnology journal · 2022Article
- NGSocomial Infections: High-Resolution Views of Hospital-Acquired Infections Through Genomic Epidemiology.Journal of the Pediatric Infectious Diseases Society · 2021Review
- The Evolving Landscape of Fungal Diagnostics, Current and Emerging Microbiological Approaches.Journal of fungi (Basel, Switzerland) · 2021Review
- Long-term Outcomes of Patients With Fungal Infections Associated With Contaminated Methylprednisolone Injections.Open forum infectious diseases · 2020Article
- Rhizopus microsporus Infections Associated with Surgical Procedures, Argentina, 2006-2014.Emerging infectious diseases · 2020Article
- Outbreak ofFrontiers in microbiology · 2020Article
- Allergic Fungal Sinusitis Caused by Exserohilum rostratum and Literature Review.Mycopathologia · 2019Review
- Update on the Epidemiology of coccidioidomycosis in the United States.Medical mycology · 2019Review
- A New Age in Molecular Diagnostics for Invasive Fungal Disease: Are We Ready?Frontiers in microbiology · 2019Review
- Article
- Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris.Emerging microbes & infections · 2018Article
- Healthcare-associated fungal outbreaks: New and uncommon species, New molecular tools for investigation and prevention.Antimicrobial resistance and infection control · 2018Review
- Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks.The Lancet. Infectious diseases · 2017Review
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exserohilum rostratum was the cause of most cases of fungal meningitis and other infections associated with the injection of contaminated methylprednisolone acetate produced by the New England Compounding Center (NECC). Until this outbreak, very few human cases of Exserohilum infection had been reported, and very little was known about this dematiaceous fungus, which usually infects plants. Here, we report using whole-genome sequencing (WGS) for the detection of single nucleotide polymorphisms (SNPs) and phylogenetic analysis to investigate the molecular origin of the outbreak using 22 isolates of E. rostratum retrieved from 19 case patients with meningitis or epidural/spinal abscesses, 6 isolates from contaminated NECC vials, and 7 isolates unrelated to the outbreak. Our analysis indicates that all 28 isolates associated with the outbreak had nearly identical genomes of 33.8 Mb. A total of 8 SNPs were detected among the outbreak genomes, with no more than 2 SNPs separating any 2 of the 28 genomes. The outbreak genomes were separated from the next most closely related control strain by ∼136,000 SNPs. We also observed significant genomic variability among strains unrelated to the outbreak, which may suggest the possibility of cryptic speciation in E. rostratum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.