ArticleApplied and environmental microbiology2014
The pH-dependent expression of the urease operon in Streptococcus salivarius is mediated by CodY.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Transcriptomic Responses of MRSA to Penicillin-Modulating Phlorotannins Derived fromMarine drugs · 2026Article
- A ComX-based strategy for artificially inducing competence in naturally non-transformableApplied and environmental microbiology · 2026Article
- Urease in acetogenicGut microbes · 2025Article
- Determining the Importance of the Stringent Response for Methicillin-Resistant Staphylococcus aureus Virulence In Vivo.The Journal of infectious diseases · 2025Article
- A novel urease gene structure of Sporosarcina pasteurii with double operons.Molecular genetics and genomics : MGG · 2025Article
- Functional Analysis of the Major Pilin Proteins of Type IV Pili inInternational journal of molecular sciences · 2024Article
- Article
- Ecophysiological and genomic analyses of a representative isolate of highly abundant Bacillus cereus strains in contaminated subsurface sediments.Environmental microbiology · 2022Article
- Identification of a Putative CodY Regulon in the Gram-Negative Phylum Synergistetes.International journal of molecular sciences · 2022Article
- Context-dependent differences in the functional responses of Lactobacillaceae strains to fermentable sugars.Frontiers in microbiology · 2022Article
- Improvement of Biomineralization ofJournal of microbiology and biotechnology · 2021Article
- Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.PLoS pathogens · 2019Article
- Impact of growth pH and glucose concentrations on the CodY regulatory network in Streptococcus salivarius.BMC genomics · 2018Article
- Bacterial profile of infant feces associated with lactation infectious breasts.Pediatric health, medicine and therapeutics · 2018Article
- [Construction of a low-pH-sensing system in Streptococcus mutans].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Article
- CodY, a master integrator of metabolism and virulence in Gram-positive bacteria.Current genetics · 2017Review
- YMC-2011, a Temperate Phage of Streptococcus salivarius 57.I.Applied and environmental microbiology · 2017Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Beyond microbial community composition: functional activities of the oral microbiome in health and disease.Microbes and infection · 2015Article
- Article
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3 authors.
Funding
Abstract
Urease gene expression in Streptococcus salivarius 57.I, a strain of one of the major alkali producers in the mouth, is induced by acidic pH and excess amounts of carbohydrate. Expression is controlled primarily at the transcriptional level from a promoter, pureI. Recent sequencing analysis revealed a CodY box located 2 bases 5' to the -35 element of pureI. Using continuous chemostat culture, transcription from pureI was shown to be repressed by CodY, and at pH 7 the repression was more pronounced than that in cells grown at pH 5.5 under both 20 and 100 mM glucose. The direct binding of CodY to pureI was demonstrated by electrophoretic mobility shift assay and chromatin immunoprecipitation (ChIP)-quantitative real-time PCR (qPCR). The result of ChIP-qPCR also confirmed that the regulation of CodY is indeed modulated by pH and the binding of CodY at neutral pH is further enhanced by a limited supply of glucose (20 mM). In the absence of CodY, the C-terminal domain of the RNA polymerase (RNAP) α subunit interacted with the AT tracks within the CodY box, indicating that CodY and RNAP compete for the same binding region. Such regulation could ensure optimal urease expression when the enzyme is most required, i.e., at an acidic growth pH with an excess amount of carbon nutrients.
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