ArticleAmerican journal of physiology. Lung cellular and molecular physiology2014
In situ determination of alveolar septal strain, stress and effective Young's modulus: an experimental/computational approach.
Article in American journal of physiology. Lung cellular and molecular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Design and In Vivo Validation of a Constant-Flow Ventilation Circuit for Tissue Stabilization During Intravital Imaging of the Lungs.Annals of biomedical engineering · 2026Article
- Mechanical stress in a solid ellipsoid model of the lung after thoracoscopic surgery for spontaneous pneumothorax.Journal of thoracic disease · 2025Article
- The fix is not yet in: recommendation for fixation of lungs within physiological/pathophysiological volume range in preclinical pulmonary structure-function studies.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-β1: a structure-function analysis.Scientific reports · 2024Article
- Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage.Frontiers in network physiology · 2024Article
- Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels.Scientific reports · 2023Article
- Baseline Stiffness Modulates the Non-Linear Response to Stretch of the Extracellular Matrix in Pulmonary Fibrosis.International journal of molecular sciences · 2021Article
- Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation, and reduces ventilation injury in a respiratory distress model.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung.Histochemistry and cell biology · 2021Article
- The Contribution of Surface Tension-Dependent Alveolar Septal Stress Concentrations to Ventilation-Induced Lung Injury in the Acute Respiratory Distress Syndrome.Frontiers in physiology · 2020Article
- Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain.Acta biomaterialia · 2019Article
- The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses.Scientific reports · 2019Article
- Simulation of blast lung injury induced by shock waves of five distances based on finite element modeling of a three-dimensional rat.Scientific reports · 2019Article
- Alveolar Micromechanics in Bleomycin-induced Lung Injury.American journal of respiratory cell and molecular biology · 2018Article
- Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Coming to terms with tissue engineering and regenerative medicine in the lung.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- A critical review of the American Journal of Physiology-Lung Cellular and Molecular Physiology: 2012-2015.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alveolar septa, which have often been modeled as linear elements, may distend due to inflation-induced reduction in slack or increase in tissue stretch. The distended septum supports tissue elastic and interfacial forces. An effective Young's modulus, describing the inflation-induced relative displacement of septal end points, has not been determined in situ for lack of a means of determining the forces supported by septa in situ. Here we determine such forces indirectly according to Mead, Takishima, and Leith's classic lung mechanics analysis (J Appl Physiol 28: 596-608, 1970), which demonstrates that septal connections transmit the transpulmonary pressure, PTP, from the pleural surface to interior regions. We combine experimental septal strain determination and computational stress determination, according to Mead et al., to calculate effective Young's modulus. In the isolated, perfused rat lung, we label the perfusate with fluorescence to visualize the alveolar septa. At eight PTP values around a ventilation loop between 4 and 25 cmH2O, and upon total deflation, we image the same region by confocal microscopy. Within an analysis region, we measure septal lengths. Normalizing by unstressed lengths at total deflation, we calculate septal strains for all PTP > 0 cmH2O. For the static imaging conditions, we computationally model application of PTP to the boundary of the analysis region and solve for septal stresses by least squares fit of an overdetermined system. From group septal strain and stress values, we find effective septal Young's modulus to range from 1.2 × 10(5) dyn/cm(2) at low P(TP) to 1.4 × 10(6) dyn/cm(2) at high P(TP).
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