Evidence map›Paper›PMID 24951760›Full record

ReviewCirculation research2014

Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium.

Francesco S Loffredo, Andriana P Nikolova, James R Pancoast, Richard T Lee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

  1. Trial
  2. Review
  3. A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  11. Article
  12. Review
  13. Evaluation of Galectin-3 in Dogs with Atrial Fibrillation.Animals : an open access journal from MDPI · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francesco S LoffredoFrom the Department of Stem Cell and Regenerative Biology, Harvard University, Brigham Regenerative Medicine Center, Cambridge, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA; and Harvard Stem Cell Institute, Cambridge, MA.
Andriana P NikolovaFrom the Department of Stem Cell and Regenerative Biology, Harvard University, Brigham Regenerative Medicine Center, Cambridge, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA; and Harvard Stem Cell Institute, Cambridge, MA.
James R PancoastFrom the Department of Stem Cell and Regenerative Biology, Harvard University, Brigham Regenerative Medicine Center, Cambridge, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA; and Harvard Stem Cell Institute, Cambridge, MA.
Richard T LeeFrom the Department of Stem Cell and Regenerative Biology, Harvard University, Brigham Regenerative Medicine Center, Cambridge, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA; and Harvard Stem Cell Institute, Cambridge, MA. RLee@Partners.org.

Funding

Aging and Myocardial Progenitor RecruitmentR01AG032977 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, RICHARD T · 2009 to 2013
$1.9M
Cardiomyocyte Lineage and Turnover by Metabolic Fate-MappingR01AG040019 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, RICHARD T · 2011 to 2015
$1.9M
Biasing Myocardial Neuregulin Signaling with Engineered LigandsR01HL117986 · NHLBI · HARVARD UNIVERSITY · PI LEE, RICHARD T · 2013 to 2016
$1.6M
NHLBI NIH HHS R01 HL117986NHLBI NIH HHS R01HL117986NIA NIH HHS R01 AG032977NIA NIH HHS R01 AG040019NIA NIH HHS R01AG040019
6 · The paper itself

Abstract

Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment options for HFpEF patients remain elusive. The lack of treatments for HFpEF reflects our very incomplete understanding of this constellation of diseases. There are many pathophysiological factors in HFpEF, but aging appears to play an important role. Here, we propose that aging of the myocardium is itself a specific pathophysiological process. New insights into the aging heart, including hormonal controls and specific molecular pathways, such as microRNAs, are pointing to myocardial aging as a potentially reversible process. While the overall process of aging remains mysterious, understanding the molecular pathways of myocardial aging has never been more important. Unraveling these pathways could lead to new therapies for the enormous and growing problem of HFpEF.

Indexed as

AgingCalcium-Binding ProteinsCalcium SignalingCyclic GMP-Dependent Protein KinasesDiastoleFibrosisHeart FailureHumansIntracellular Signaling Peptides and ProteinsMatrix MetalloproteinasesMicroRNAsMitochondriaMyocardiumSirtuinsStroke VolumeTelomereCalcium-Binding ProteinsCyclic GMP-Dependent Protein KinasesIntracellular Signaling Peptides and ProteinsMatrix MetalloproteinasesMicroRNAsRGN protein, humanSIRT6 protein, humanSirtuinsagingdiastolic dysfunctionheart failure, diastolic

Identifiers

PMID24951760
PMCPMC4094348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.