ArticleThe oncologist2014
Estimates of young breast cancer survivors at risk for infertility in the U.S.
Article in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women.The Cochrane database of systematic reviews · 2019Pooled it
- Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists.Journal of assisted reproduction and genetics · 2018Pooled it
- Pooled it
- Perspectives on fertility preservation among women living with breast cancer in Ghana.BMC women's health · 2025Article
- The necessity of adjuvant chemotherapy in young patients with TClinical and experimental medicine · 2025Article
- Rapamycin inhibits tamoxifen-induced endometrial proliferation in vitro as a pilot approach for endometrial protection in breast cancer.Scientific reports · 2025Article
- Balancing Fertility Preservation and Treatment Efficacy in (Neo)adjuvant Therapy for Adolescent and Young Adult Breast Cancer Patients: a Narrative Review.Current oncology reports · 2024Review
- Reproductive Outcomes in Young Breast Cancer Survivors Treated (15-39) in Ontario, Canada.Current oncology (Toronto, Ont.) · 2022Article
- Fertility Preservation in Young Women with Breast Cancer: Impact on Treatment and Outcomes.Annals of surgical oncology · 2022Article
- Factors Associated with Unplanned Pregnancy Among Cancer Survivors.Journal of women's health (2002) · 2022Article
- Productivity costs associated with metastatic breast cancer in younger, midlife, and older women.Cancer · 2020Article
- Fertility in Breast Cancer Survivors in the Middle East: A Retrospective Study.Breast (Edinburgh, Scotland) · 2020Article
- Medical costs associated with metastatic breast cancer in younger, midlife, and older women.Breast cancer research and treatment · 2020Article
- Breast cancer: an update on treatment-related infertility.Journal of cancer research and clinical oncology · 2020Review
- Chemotherapy Associated Ovarian Failure.Frontiers in endocrinology · 2020Review
- Fertility-related experiences after breast cancer diagnosis in the Sister and Two Sister Studies.Cancer · 2019Article
- Medical costs of treating breast cancer among younger Medicaid beneficiaries by stage at diagnosis.Breast cancer research and treatment · 2017Article
- Preservation of Fertility or Ovarian Function in Patients with Breast Cancer or Gynecologic and Internal Malignancies.Geburtshilfe und Frauenheilkunde · 2017Article
- Breast cancer treatment costs in younger, privately insured women.Breast cancer research and treatment · 2017Article
- Fertility Preservation for the Young Breast Cancer Patient.Annals of surgical oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundStandard treatments for breast cancer can impair fertility. It is unknown how many U.S. survivors are at risk for infertility. We estimated the population at risk for infertility secondary to treatment among reproductive-aged breast cancer survivors.
methodsWe combined data from three sources: the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results cancer registry data on incident breast cancers diagnosed in women aged 15-44 years between 2004 and 2006; treatment data from NPCR's 2004 Breast and Prostate Cancer Data Quality and Patterns of Care (PoC) study; and data on women's intentions to have children from the 2006-2010 National Survey of Family Growth (NSFG).
resultsIn the cancer registry data, an average of 20,308 women with breast cancer aged <45 years were diagnosed annually. Based on estimates from PoC data, almost all of these survivors (97%, 19,416 women) were hormone receptor positive or received chemotherapy and would be at risk for infertility. These women need information about the impact of treatments on fertility. Estimates based on NSFG data suggest approximately half of these survivors (9,569 women) might want children and could benefit from fertility counseling and fertility preservation.
conclusionNearly all young breast cancer survivors in the U.S. are at risk for infertility. Physicians should discuss the potential impact of treatment on fertility. A smaller but sizeable number of at-risk survivors may be interested in having children. Given the magnitude of potential infertility and its quality-of-life implications, these survivors should have access to and potential coverage for fertility services.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.