ArticleSchizophrenia research2014
Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Functional Neuroimaging Meta-Analysis of Self-Related Processing in Schizophrenia.Frontiers in neurology · 2019Pooled it
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Multidimensional neural representations of social features during movie viewing.Social cognitive and affective neuroscience · 2024Article
- Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.Scientific reports · 2021Observational
- Real-time fMRI feedback impacts brain activation, results in auditory hallucinations reduction: Part 1: Superior temporal gyrus -Preliminary evidence.Psychiatry research · 2020Article
- Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.Human brain mapping · 2019Article
- Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia.Schizophrenia research · 2016Article
- A New Perspective on Delusional States - Evidence for Claustrum Involvement.Frontiers in psychiatry · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDeficits in the capacity to reflect about the self and others ("social reflection" [SR]) have been identified in schizophrenia, as well as in people with a genetic or clinical risk for the disorder. However, the neural underpinnings of these abnormalities are incompletely understood.
methodsResponses of a network of brain regions known to be involved in self and other processing (e.g., medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and superior temporal gyrus (STG)) were measured during SR in 16 first-degree, non-psychotic relatives (RELS) of schizophrenia patients and 16 healthy controls (CONS). Because of prior evidence linking dysfunction in this network and delusions, associations between SR-related responses of this network and subclinical delusions (measured using the Peters et al. Delusions Inventory) were also examined.
resultsCompared with CONS, RELS showed significantly less SR-related activity of the right and left PCC and STG. Moreover, response magnitudes were negatively correlated with levels of delusional thinking across both groups.
conclusionsThese findings suggest that aberrant function of the neural circuitry underpinning SR is associated with the genetic liability to schizophrenia and confers vulnerability to delusional beliefs.
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Registered trials
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