Evidence map›Paper›PMID 24951239›Full record

ReviewCurrent allergy and asthma reports2014

The placebo effect in asthma.

Stefanie Dutile, Ted J Kaptchuk, Michael E Wechsler

Registry-linked trialAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04129931 (PrecISE), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04129931 phase2completednot on this mapstarted 2019, after this paper: background citation

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2025Enrolled950ConditionsAsthmaArmsMCT, Clazakizumab, Broncho-Vaxom, Imatinib Mesylate, Cavosonstat
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
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  8. Article
  9. Placebo: a brief updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefanie DutileBrigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ted J Kaptchuk
Michael E Wechsler

Funding

Mentoring and Research in Placebo Studies, Asian Medicine, and CAMK24AT004095 · NCCIH · HARVARD MEDICAL SCHOOL · PI KAPTCHUK, TED · 2007 to 2016
$1.4M
NCCIH NIH HHS 2 K24 AT004095NCCIH NIH HHS K24 AT004095
6 · The paper itself

Abstract

The placebo effect is a complex phenomenon occurring across a variety of clinical conditions. While much placebo research has been conducted in diseases defined by self-report such as depression, chronic pain, and irritable bowel syndrome (IBS), asthma has been proposed as a useful model because of its easily measured objective outcomes. Studies examining the placebo response in asthma have not only contributed to an understanding of the mechanisms behind the placebo response but also shed an interesting light on the current treatment and diagnosis of asthma. This paper will review current literature on placebos in general and specifically on the placebo response in asthma. It focuses on what we know about the mechanisms behind the placebo effect, whether there is a specific portion of the population who responds to placebos, which patient outcomes are influenced by the placebo effect, and whether the effect can be augmented.

Indexed as

AsthmaClinical Trials as TopicHumansModels, ImmunologicalPlacebo EffectTreatment Outcome

Identifiers

PMID24951239
PMCPMC4351653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.