Evidence map›Paper›PMID 24951127›Full record

ArticleMaternal and child health journal2015

Clinical correlates of prescription opioid analgesic use in pregnancy.

Megan V Smith, Darce Costello, Kimberly A Yonkers

Open access · greenAbstract read
In one paragraph

Article in Maternal and child health journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  4. Timing of treatment for opioid use disorder among birthing people.Journal of substance use and addiction treatment · 2024
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  11. A nation-wide Swedish study of opioid analgesic prescribing patterns during pregnancy and associated preexisting mental health conditions.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan V SmithDepartment of Psychiatry, Yale School of Medicine, 300 George Street, 9th floor, New Haven, CT, 06511, USA, megan.smith@yale.edu.
Darce Costello
Kimberly A Yonkers
Yale University · US

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Effects of Perinatal Depression on PTD and LBWR01HD045735 · NICHD · YALE UNIVERSITY · PI YONKERS, KIMBERLY A · 2004 to 2008
$4.6M
Project START: Screening to Augment Referral to TreatmentR01DA027194 · NIDA · YALE UNIVERSITY · PI MARTINO, STEVE, YONKERS, KIMBERLY A · 2010 to 2014
$3.3M
Yale BIRCWH Scholar Program on Women's Health and Addictive BehaviorsK12DA031050 · NIDA · YALE UNIVERSITY · PI MAZURE, CAROLYN M. · 2010 to 2014
$2.5M
Psychosocial Res. to Improve Drug Treatment in PregnancyR01DA019135 · NIDA · YALE UNIVERSITY · PI YONKERS, KIMBERLY A · 2004 to 2008
$2.4M
Progesterone for Postpartum Cocaine RelapseR21DA029914 · NIDA · YALE UNIVERSITY · PI SOFUOGLU, MEHMET, YONKERS, KIMBERLY A · 2010 to 2011
$448k
NCATS NIH HHS UL1 TR000142NICHD NIH HHS R01 HD045735NIDA NIH HHS K12 DA031050NIDA NIH HHS R01 DA019135NIDA NIH HHS R01 DA027194NIDA NIH HHS R21 DA029914
6 · The paper itself

Abstract

A 2012 committee opinion from the American College of Obstetricians and Gynecologists highlights the considerable increase in opioid addiction in recent years, yet little is known about clinical correlates of prescribed opioids among pregnant women. This study examines clinical and demographic factors associated with the use of opioid analgesics in pregnancy. Data were derived from a prospective cohort study of pregnant women. Participants were administered the Composite International Diagnostic Interview to identify depressive and anxiety disorders and data on medication use were gathered at three assessment points and classified according to the Anatomical Therapeutic Chemical Code (ATC) classification system ATC group N02A. Participants included 2,748 English or Spanish speaking pregnant women. Six percent (n = 165) of women used opioid analgesics at any point in pregnancy. More pregnant women using opioids met diagnostic criteria for major depressive disorder (16 vs. 8 % for non users), generalized anxiety disorder (18 vs. 9 % for non users), post-traumatic stress disorder (11 vs. 4 % for non users) and panic disorder (6 vs. 4 % for non users). Women who reported opioid use were also significantly more likely than non users to report using illicit drugs and almost three times as likely to report smoking cigarettes in the second or third trimester of pregnancy (4 and 23 %, respectively) as compared to non-opioid users (0.5 and 8 %). The use of opioids in pregnancy was associated with higher levels of psychiatric comorbidity and use of other substances as compared to non-opioid users.

Indexed as

AdultAnalgesics, OpioidAnxiety DisordersComorbidityDrug PrescriptionsFemaleHumansIllicit DrugsMajor Depressive DisorderOpioid-Related DisordersPainPregnancyPrevalenceProspective StudiesRegression AnalysisRisk FactorsAnalgesics, OpioidIllicit Drugs

Identifiers

PMID24951127
PMCPMC4272915
OpenAlexW2064171903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.