SynthesisMaturitas2014
Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.
Synthesis in Maturitas, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Nutritional interventions in treating menopause-related sleep disturbances: a systematic review.Nutrition reviews · 2024Pooled it
- Pooled it
- Guideline
- Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2017Guideline
- Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials.Oncotarget · 2016Pooled it
- Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.European journal of nutrition · 2025Trial
- Trial
- Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.PloS one · 2017Trial
- Assessing the Relationship Between Depressive Symptoms and Menopausal Quality of Life Among Academic Women in Saudi Arabia.Healthcare (Basel, Switzerland) · 2025Article
- DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.).Phytochemistry · 2023Article
- Combination of Soy Isoflavones, 8-Prenylnaringenin and Melatonin Improves Hot Flashes and Health-Related Quality of Life Outcomes in Postmenopausal Women: Flavie Study.Journal of menopausal medicine · 2023Article
- Heart Failure in Menopause: Treatment and New Approaches.International journal of molecular sciences · 2022Review
- [Preventive activities in women. PAPPS update 2022].Atencion primaria · 2022Article
- Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials.Nutrition research and practice · 2022Review
- Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview.International journal of molecular sciences · 2021Review
- [Preventive activities in women's care].Atencion primaria · 2020Article
- The association between soy isoflavone intake and menopausal symptoms after breast cancer diagnosis: a prospective longitudinal cohort study on Chinese breast cancer patients.Breast cancer research and treatment · 2020Article
- A Nutraceutical Approach to Menopausal Complaints.Medicina (Kaunas, Lithuania) · 2019Review
- Effect of S-equol and Soy Isoflavones on Heart and Brain.Current cardiology reviews · 2019Review
- Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
aimsReview controlled clinical trials of isoflavones and amino acid preparation effects on hot flashes and at least one other symptom including mood, sleep, pain, and cognitive function that women report during the menopausal transition and early postmenopause.
methodsAn experienced reference librarian searched PubMed/Medline, CINAHL Plus, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, AMED, and Alt-Health Watch for English-language randomized controlled trials between 2004 and July 2011. Seventeen trials of isoflavones and amino acid effects on hot flashes and one additional symptom were identified.
resultsIn five trials of soy isoflavone preparations, two (6g soy germ extract and 25 g soy protein in soy nuts) significantly decreased hot flashes, but no other symptoms. In the seven trials of other isoflavones, six significantly reduced hot flashes; in addition, red clover (80 mg) significantly reduced mood symptoms; Rexflavone (350 mg) for women with Kupperman Index>20 significantly reduced sleep symptoms; two trials had significant reductions for pain: isoflavone powder (90 mg) and red clover (80 mg). The only trial in this systematic review that significantly reduced cognitive symptoms was red clover (80 mg). In one trial, red clover isoflavone (80 mg/day) significantly relieved hot flashes, mood, pain, and cognitive symptoms. Amino acids yielded no significant results. Equol supplements of 30 mg/day for non-Equol producing women significantly reduced mood symptoms in one trial. The magnolia bark extract combination significantly reduced hot flashes, mood, and sleep symptoms.
conclusionsIsoflavone trials yielded significant reductions on hot flashes and co-occurring symptoms during the menopausal transition and postmenopause, but studies require replication with larger sample sizes and attention to measurement of outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.