ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2015
Rethinking stimulation of the brain in stroke rehabilitation: why higher motor areas might be better alternatives for patients with greater impairments.
Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03868410 (A Novel Approach for Brain Stimulation in Severe Stroke), which is not on this map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Novel Approach for Brain Stimulation in Severe Stroke
Who cites it
53 citing papers in PubMed.
- EEG-fMRI neurofeedback versus motor imagery after stroke, a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Stimulation of the Premotor Cortex Enhances Interhemispheric Functional Connectivity in Association with Upper Limb Motor Recovery in Moderate-to-Severe Chronic Stroke.Brain connectivity · 2023Trial
- Anti-spastic effect of contralesional dorsal premotor cortex stimulation in stroke patients with moderate-to-severe spastic paresis: a randomized, controlled pilot trial.Acta neurologica Belgica · 2023Trial
- Bilateral Contralaterally Controlled Functional Electrical Stimulation Reveals New Insights Into the Interhemispheric Competition Model in Chronic Stroke.Neurorehabilitation and neural repair · 2019Trial
- Stimulation targeting higher motor areas in stroke rehabilitation: A proof-of-concept, randomized, double-blinded placebo-controlled study of effectiveness and underlying mechanisms.Restorative neurology and neuroscience · 2015Trial
- Altered Functional Connectivity Between Cortical Premotor Areas and the Spinal Cord in Chronic Stroke.Stroke · 2025Article
- Effects of repetitive transcranial magnetic stimulation on upper extremity motor function in stroke survivors: study protocol of a randomized sham-controlled trial.Frontiers in neurology · 2025Article
- Early corticospinal tract sub-pathway lesion load and integrity predict post-stroke motor outcomes.Frontiers in human neuroscience · 2025Article
- Stage-dependent role of interhemispheric pathway for motor recovery in primates.Nature communications · 2024Article
- Modulation of the Association Between Corticospinal Tract Damage and Outcome After Stroke by White Matter Hyperintensities.Neurology · 2024Article
- White matter hyperintensities modify relationships between corticospinal tract damage and motor outcomes after stroke.medRxiv : the preprint server for health sciences · 2023Article
- Correlation between the ERD in grasp/open tasks of BCIs and hand function of stroke patients: a cross-sectional study.Biomedical engineering online · 2023Article
- Use of multi-perturbation Shapley analysis in lesion studies of functional networks: The case of upper limb paresis.Human brain mapping · 2023Article
- Recovered grasping performance after stroke depends on interhemispheric frontoparietal connectivity.Brain : a journal of neurology · 2023Article
- Pathway-Specific Mediation Effect Between Structure, Function, and Motor Impairment After Subcortical Stroke.Neurology · 2023Article
- Functional-oriented, portable brain-computer interface training for hand motor recovery after stroke: a randomized controlled study.Frontiers in neuroscience · 2023Article
- Evaluation of fMRI activation in post-stroke patients with movement disorders after repetitive transcranial magnetic stimulation: a scoping review.Frontiers in neurology · 2023Article
- The behavioral and neural effects of parietal theta burst stimulation on the grasp network are stronger during a grasping task than at rest.Frontiers in neuroscience · 2023Article
- The assessment of interhemispheric imbalance using functional near-infrared spectroscopic and transcranial magnetic stimulation for predicting motor outcome after stroke.Frontiers in neuroscience · 2023Article
- A New Framework to Interpret Individual Inter-Hemispheric Compensatory Communication after Stroke.Journal of personalized medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Stimulating the brain to drive its adaptive plastic potential is promising to accelerate rehabilitative outcomes in stroke. The ipsilesional primary motor cortex (M1) is invariably facilitated. However, evidence supporting its efficacy is divided, indicating that we may have overgeneralized its potential. Since the M1 and its corticospinal output are frequently damaged in patients with serious lesions and impairments, ipsilesional premotor areas (PMAs) could be useful alternates instead. We base our premise on their higher probability of survival, greater descending projections, and adaptive potential, which is causal for recovery across the seriously impaired. Using a conceptual model, we describe how chronically stimulating PMAs would strongly affect key mechanisms of stroke motor recovery, such as facilitating the plasticity of alternate descending output, restoring interhemispheric balance, and establishing widespread connectivity. Although at this time it is difficult to predict whether PMAs would be "better," it is important to at least investigate whether they are reasonable substitutes for the M1. Even if the stimulation of the M1 may benefit those with maximum recovery potential, while that of PMAs may only help the more disadvantaged, it may still be reasonable to achieve some recovery across the majority rather than stimulate a single locus fated to be inconsistently effective across all.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.