Evidence map›Paper›PMID 24950692›Full record

ArticleJournal of lipid research2014

Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate.

Iryna Sutter, Rebekka Park, Alaa Othman, Lucia Rohrer, Thorsten Hornemann, Markus Stoffel, Olivier Devuyst, Arnold von Eckardstein

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  13. High-Density Lipoprotein Function in Cardiovascular Disease and Diabetes Mellitus.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
  14. Article
  15. Review
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  17. Article
  18. Resveratrol exerts a biphasic effect on apolipoprotein M.British journal of pharmacology · 2016
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Iryna SutterInstitute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland; Competence Center for Integrated Human Physiology and Institute of Physiology.
Rebekka ParkETH Zurich, Zurich, Switzerland; and Competence Center for Systems Physiology and Metabolic Diseases ETH Zurich and University of Zurich, Zurich, Switzerland.
Alaa OthmanInstitute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland; Competence Center for Integrated Human Physiology ETH Zurich and University of Zurich, Zurich, Switzerland.
Lucia RohrerInstitute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland; Competence Center for Integrated Human Physiology and Institute of Physiology.
Thorsten HornemannInstitute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland; Competence Center for Integrated Human Physiology and Institute of Physiology.
Markus StoffelETH Zurich, Zurich, Switzerland; and Competence Center for Systems Physiology and Metabolic Diseases ETH Zurich and University of Zurich, Zurich, Switzerland.
Olivier Devuystand Institute of Physiology University of Zurich, Zurich, Switzerland; Institute of Molecular Health Sciences.
Arnold von EckardsteinInstitute of Clinical Chemistry, University and University Hospital of Zurich, Zurich, Switzerland; Competence Center for Integrated Human Physiology and Institute of Physiology ETH Zurich and University of Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHETH Zurich · CHInstitute of Molecular Medicine · INSupply Chain Competence Center (Germany) · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosine-1-phosphate (S1P) mediates several cytoprotective functions of HDL. apoM acts as a S1P binding protein in HDL. Erythrocytes are the major source of S1P in plasma. After glomerular filtration, apoM is endocytosed in the proximal renal tubules. Human or murine HDL elicited time- and dose-dependent S1P efflux from erythrocytes. Compared with HDL of wild-type (wt) mice, S1P efflux was enhanced in the presence of HDL from apoM transgenic mice, but not diminished in the presence of HDL from apoM knockout (Apom(-/-)) mice. Artificially reconstituted and apoM-free HDL also effectively induced S1P efflux from erythrocytes. S1P and apoM were not measurable in the urine of wt mice. Apom(-/-) mice excreted significant amounts of S1P. apoM was detected in the urine of mice with defective tubular endocytosis because of knockout of the LDL receptor-related protein, chloride-proton exchanger ClC-5 (Clcn5(-/-)), or the cysteine transporter cystinosin. Urinary levels of S1P were significantly elevated in Clcn5(-/-) mice. In contrast to Apom(-/-) mice, these mice showed normal plasma concentrations for apoM and S1P. In conclusion, HDL facilitates S1P efflux from erythrocytes by both apoM-dependent and apoM-independent mechanisms. Moreover, apoM facilitates tubular reabsorption of S1P from the urine, however, with no impact on S1P plasma concentrations.

Indexed as

AnimalsApolipoproteins MErythrocytesKidney TubulesLipoproteins, HDLLysophospholipidsMiceMice, KnockoutSphingosineApolipoproteins MApoM protein, mouseLipoproteins, HDLLysophospholipidsSphingosinesphingosine 1-phosphatechloride-proton exchanger ClC5cystinosinhigh density lipoproteinkidneymegalin

Identifiers

PMID24950692
PMCPMC4109767
OpenAlexW2103355687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.