ArticleClinical oral investigations2015
Photodynamic killing of Enterococcus faecalis in dentinal tubules using mTHPC incorporated in liposomes and invasomes.
Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Electrically Charged Lipid Nanoparticles as Intracanal Antimicrobial Delivery Systems: A Narrative Review of Preclinical Evidence for Biofilm Control.Dentistry journal · 2026Review
- Laser Therapy in the Management of Endodontic-Periodontal Lesions: A Comprehensive Review of Clinical Efficacy and Therapeutic Applications.Journal of lasers in medical sciences · 2026Review
- Nanocarrier-based Drug Delivery Systems to Enhance Antimicrobial Photodynamic Therapy in Dental Applications: A Review.AAPS PharmSciTech · 2025Review
- Effect of ultrasonic agitation of methylene blue during the antimicrobial photodynamic therapy in reducing viable cells from a multispecies biofilm and endotoxins: an in vitro study.Lasers in medical science · 2025Article
- Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions.Journal of functional biomaterials · 2025Review
- Nanomaterial-based drug-delivery system as an aid to antimicrobial photodynamic therapy in treating oral biofilm.Future microbiology · 2024Review
- Photodynamic Suppression of Enterococcus Faecalis in Infected Root Canals with Indocyanine Green, TroloxPharmaceutics · 2023Article
- Nanotechnology for Dentistry: Prospects and Applications.Nanomaterials (Basel, Switzerland) · 2023Review
- Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study.International journal of molecular sciences · 2023Article
- Comparison of the Treatment Efficacy of Endo-Perio Lesions Using a Standard Treatment Protocol and Extended by Using a Diode Laser (940 nm).Journal of clinical medicine · 2022Article
- Review
- Antibacterial Effect of Endodontic Disinfections on Enterococcus Faecalis in Dental Root Canals-An In-Vitro Model Study.Materials (Basel, Switzerland) · 2021Article
- Pivotal Local Drug Delivery Systems in Endodontics; A Review of Literature.Iranian endodontic journal · 2020Review
- An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics-A Critical Review.Journal of functional biomaterials · 2019Article
- Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present in vitro study investigates the antimicrobial photodynamic efficiency of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC) incorporated in liposomes (LIP) and highly flexible invasomes (INV) on the endodontopathogenic species Enterococcus faecalis in infected dental root canals. MATERIALS AND
methodsA total of 48 root canals were prepared mechanically to file size ISO 50 and inoculated with E. faecalis for 48 h. In the test groups, the infected root canals were subjected to aPDT with either mTHPC linked to LIP or INV. The controls were either incubated with 1 % chlorohexidine gel (CHX, positive control) or root canals were irrigated with normal saline (NaCl, negative control). After treatment all canals were mechanically enlarged (ISO 50-110), and the debris of each filing process was subjected to bacterial culture analysis.
resultsBoth mTHPC formulations showed a significant antimicrobial effect. A bacterial reduction by up to 3.6 log-steps was ascertained for INV directly at the root canal wall. aPDT using INV (ISO 60) was more effective than CHX, which caused a decrease in only 1.2 log-steps. It was found that both liposomal mTHPC formulations were capable to suppress E. faecalis inside the dentinal tubules up to 300 μm.
conclusionsThe results show that mTHPC linked to LIP and INV is capable of efficiently reducing E. faecalis in dental root canals. CLINICAL RELEVANCE: As evidenced, E. faecalis is resistant to several conventional antibacterial treatment measures. In this context, photodynamic treatment with mTHPC delivered by INV is superior to temporary dressing with 1 % CHX gel applied for 24 h.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.