Evidence map›Paper›PMID 24950377›Full record

ArticleMolecular cell2014

RETRACTED: PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage.

Stuart G Jarrett, Erin M Wolf Horrell, Perry A Christian, Jillian C Vanover, Mary C Boulanger, Yue Zou, John A D'Orazio

RetractedOpen access · bronzeAbstract readRetracted Publication
In one paragraph

Article in Molecular cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 84 citations in OpenAlex.

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  8. METTL14 facilitates global genome repair and suppresses skin tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stuart G JarrettMarkey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Erin M Wolf HorrellMarkey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Perry A ChristianGraduate Center for Toxicology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Jillian C VanoverDepartment of Pharmacology and Nutrition Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Mary C BoulangerDepartment of Dietetics and Human Nutrition, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Yue ZouDepartment of Biochemistry and Molecular Biology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
John A D'OrazioMarkey Cancer Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Graduate Center for Toxicology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Pharmacology and Nutrition Sciences, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Dietetics and Human Nutrition, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: jdorazio@uky.edu.
University of Kentucky · USThe Graduate Center, CUNY · USEast Tennessee State University · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.T32ES007266 · NIEHS · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI, MELLON, ISABEL W · 1990 to 2020
$3.7M
The role of Mc1r in melanocytic UV-induced DNA damage and repair responsesR01CA131075 · NCI · UNIVERSITY OF KENTUCKY · PI D'ORAZIO, JOHN A · 2010 to 2020
$3.3M
Interdisciplinary Research Training in Cancer BiologyT32CA165990 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers, KATHLEEN L. O'CONNOR · 2013 to 2026
$3.2M
Coleus forskohlii extract: melanization and UV protection by a natural productR21CA127052 · NCI · UNIVERSITY OF KENTUCKY · PI D'ORAZIO, JOHN A · 2008 to 2009
$442k
Defining the role of MC1R in UV-induced oxidative damage and DNA repairR03CA125782 · NCI · UNIVERSITY OF KENTUCKY · PI D'ORAZIO, JOHN A · 2007 to 2008
$147k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1TR000117NCI NIH HHS R01 CA131075NCI NIH HHS R03 CA125782NCI NIH HHS R21 CA127052NCI NIH HHS T32 CA165990NCI NIH HHS T32CA165990NIEHS NIH HHS ES07266NIEHS NIH HHS T32 ES007266
6 · The paper itself

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. An investigation by the University of Kentucky (UK) recently determined that it contains fabricated and/or falsified data committed by the lead author on the paper. The results of the investigation can be viewed at https://ori.hhs.gov/content/case-summary-jarrett-stuart-g. UK identified that there were duplications and flips of panels in three figures (Figures 7D, 7E, and S3C), and original data could not be retrieved. In Figures 7D and 7E, there are inappropriate loading controls: reuse and relabeling between Figure 7D (no UV) and Figure 7E (+ UV). In Figure S3C, the loading controls for 6-4 PP (second row down) are the same as those for XPA (fourth row down), but are flipped. In both cases, the authors could not recover the original data, since primary data were stored only on a computer associated with a Storm PhosphorImager and were lost when that computer crashed. Thus, this is considered data fabrication, and the authors are retracting the paper. The authors apologize to the scientific community for any inconveniences or challenges resulting from the publication and retraction of this manuscript. Authors Stuart Jarrett and Jillian Vanover could not be reached. The remaining authors agree to the retraction.

Indexed as

DNA DamageAnimalsAtaxia Telangiectasia Mutated ProteinsCell Line, TumorCyclic AMP-Dependent Protein KinasesDNA-Binding ProteinsDNA RepairHEK293 CellsHumansMCF-7 CellsMiceMice, Inbred C57BLMutagenesisPhosphorylationPigmentationProtein Processing, Post-TranslationalAtaxia Telangiectasia Mutated ProteinsATR protein, humanCyclic AMP-Dependent Protein KinasesDNA-Binding ProteinsReceptor, Melanocortin, Type 1RNA, Small InterferingXeroderma Pigmentosum Group A ProteinXPA protein, human

Identifiers

PMID24950377
PMCPMC4076709
OpenAlexW2038180878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.