ArticlePloS one2014
Functional dissection of sugar signals affecting gene expression in Arabidopsis thaliana.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- cis- and trans-elements for the transcriptional regulation of sugar responsive genes: from current knowledge to future applications.Plant molecular biology · 2025Review
- Transcriptomic-proteomic analysis reveals the regulatory mechanisms of Alfalfa (Frontiers in plant science · 2025Article
- A comprehensive assessment of photosynthetic acclimation to shade in C4 grass (Cynodon dactylon (L.) Pers.).BMC plant biology · 2024Article
- Micropropagation and Genetic Fidelity of Fegra Fig (Plants (Basel, Switzerland) · 2024Article
- Inducible Pluripotent Suspension Cell Cultures (iPSCs) to Study Plant Cell Differentiation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Transcriptomic and Metabolomic Profiling Reveals the Variations in Carbohydrate Metabolism between Two Blueberry Cultivars.International journal of molecular sciences · 2023Article
- Physiological and Transcriptomic Analyses Reveal the Effects of Elevated Root-Zone COInternational journal of molecular sciences · 2022Article
- TOP1α fine-tunes TOR-PLT2 to maintain root tip homeostasis in response to sugars.Nature plants · 2022Article
- Genetic Architecture and Genome-Wide Adaptive Signatures Underlying Stem Lenticel Traits inInternational journal of molecular sciences · 2021Article
- Serendipita indica changes host sugar and defense status in Arabidopsis thaliana: cooperation or exploitation?Planta · 2021Article
- Article
- Self-Incompatibility Triggers Irreversible Oxidative Modification of Proteins in Incompatible Pollen.Plant physiology · 2020Article
- Isolation and characterization of hexokinase genes PsHXK1 and PsHXK2 from tree peony (Paeonia suffruticosa Andrews).Molecular biology reports · 2020Article
- Transcriptional Regulation in Rocket Leaves as Affected by Salinity.Plants (Basel, Switzerland) · 2019Article
- Glycation of Plant Proteins: Regulatory Roles and Interplay with Sugar Signalling?International journal of molecular sciences · 2019Review
- An Overview of Sucrose Synthases in Plants.Frontiers in plant science · 2019Review
- UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, ProvidingFrontiers in plant science · 2018Review
- The structure-activity relationship of the salicylimide derived inhibitors of UDP-sugar producing pyrophosphorylases.Plant signaling & behavior · 2018Article
- Cell-Type Specific Metabolic Flux Analysis: A Challenge for Metabolic Phenotyping and a Potential Solution in Plants.Metabolites · 2017Article
- Dynamic and diverse sugar signaling.Current opinion in plant biology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSugars modulate expression of hundreds of genes in plants. Previous studies on sugar signaling, using intact plants or plant tissues, were hampered by tissue heterogeneity, uneven sugar transport and/or inter-conversions of the applied sugars. This, in turn, could obscure the identity of a specific sugar that acts as a signal affecting expression of given gene in a given tissue or cell-type. METHODOLOGY/PRINCIPAL
findingsTo bypass those biases, we have developed a novel biological system, based on stem-cell-like Arabidopsis suspension culture. The cells were grown in a hormone-free medium and were sustained on xylose as the only carbon source. Using functional genomics we have identified 290 sugar responsive genes, responding rapidly (within 1 h) and specifically to low concentration (1 mM) of glucose, fructose and/or sucrose. For selected genes, the true nature of the signaling sugar molecules and sites of sugar perception were further clarified using non-metabolizable sugar analogues. Using both transgenic and wild-type A. thaliana seedlings, it was shown that the expression of selected sugar-responsive genes was not restricted to a specific tissue or cell type and responded to photoperiod-related changes in sugar availability. This suggested that sugar-responsiveness of genes identified in the cell culture system was not biased toward heterotrophic background and resembled that in whole plants.
conclusionsAltogether, our research strategy, using a combination of cell culture and whole plants, has provided an unequivocal evidence for the identity of sugar-responsive genes and the identity of the sugar signaling molecules, independently from their inter-conversions or use for energy metabolism.
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