Evidence map›Paper›PMID 24950206›Full record

ArticleImmunity2014

Of worms and men: HLH-30 and TFEB regulate tolerance to infection.

George R Tiller, Danielle A Garsin

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.American journal of physiology. Lung cellular and molecular physiology · 2017
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George R TillerUniversity of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA.
Danielle A GarsinUniversity of Texas Health Science Center, Houston Department of Microbiology and Molecular Genetics, 6431 Fannin Street, MSB 1.168, Houston, TX 77030, USA. Electronic address: danielle.a.garsin@uth.tmc.edu.
The University of Texas Health Science Center at Houston · US

Funding

The Role of Reactive Oxygen Species in Mucosal Innate ImmunityR01AI076406 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2009 to 2019
$3.2M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Post-initiation regulatory mechanisms controlling ethanolamine utilizationR56AI110432 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A, WINKLER, WADE · 2014 to 2014
$431k
NIAID NIH HHS R01 AI076406NIAID NIH HHS R56 AI110432NIAID NIH HHS T32 AI055449
6 · The paper itself

Abstract

In this issue of Immunity, Visvikis et al. (2014) use the model host Caenorhabditis elegans to discover a role in innate immunity for the basic helix-loop-helix transcription factor, HLH-30. The finding inspires study of the mammalian ortholog TFEB, in which a similar role in immune response is ascertained.

Indexed as

AnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsStaphylococcal InfectionsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHLH-30 protein, C elegansTcfeb protein, mouse

Identifiers

PMID24950206
PMCPMC4126603
OpenAlexW1978675824

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.