ArticlePloS one2014
Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Amelogenin Phosphorylation Affects Key Regulatory Genes in the Enamel Organ.Calcified tissue international · 2026Review
- Challenges of Studying Amelogenesis in Gene-Targeted Mouse Models.International journal of molecular sciences · 2025Review
- Epigenetic aging of semen is associated with inflammation.Epigenetics · 2024Article
- Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8Journal of experimental & clinical cancer research : CR · 2024Article
- Novel insights into the potential applications of stem cells in pulmonary hypertension therapy.Respiratory research · 2024Review
- Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins.Journal of dental research · 2024Article
- Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.The Journal of steroid biochemistry and molecular biology · 2023Article
- Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.Communications biology · 2023Article
- Plasticity of Dental Cell Types in Development, Regeneration, and Evolution.Journal of dental research · 2023Review
- Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex.International journal of molecular sciences · 2023Review
- MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway.International journal of molecular sciences · 2022Article
- Article
- Transcriptional Regulation of Dental Epithelial Cell Fate.International journal of molecular sciences · 2020Review
- G protein-coupled receptorThe Journal of biological chemistry · 2020Article
- Article
- Single-Cell RNA-Sequencing From Mouse Incisor Reveals Dental Epithelial Cell-Type Specific Genes.Frontiers in cell and developmental biology · 2020Article
- Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.PloS one · 2020Article
- Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo.Cells · 2019Article
- Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology.The Journal of biological chemistry · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Cell fates are determined by specific transcriptional programs. Here we provide evidence that the transcriptional coactivator, Mediator 1 (Med1), is essential for the cell fate determination of ectodermal epithelia. Conditional deletion of Med1 in vivo converted dental epithelia into epidermal epithelia, causing defects in enamel organ development while promoting hair formation in the incisors. We identified multiple processes by which hairs are generated in Med1 deficient incisors: 1) dental epithelial stem cells lacking Med 1 fail to commit to the dental lineage, 2) Sox2-expressing stem cells extend into the differentiation zone and remain multi-potent due to reduced Notch1 signaling, and 3) epidermal fate is induced by calcium as demonstrated in dental epithelial cell cultures. These results demonstrate that Med1 is a master regulator in adult stem cells to govern epithelial cell fate.
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