Evidence map›Paper›PMID 24949971›Full record

ArticleCell2014

Polar body genome transfer for preventing the transmission of inherited mitochondrial diseases.

Tian Wang, Hongying Sha, Dongmei Ji, Helen L Zhang, Dawei Chen, Yunxia Cao, Jianhong Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Therapeutic Impact of Mitochondrial Transplants for Cardiovascular Diseases.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Causes of and Solutions to Mitochondrial Disorders: A Literature Review.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Spatiotemporal Distribution and Function of Mitochondria in Oocytes.Reproductive sciences (Thousand Oaks, Calif.) · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tian WangState Key Laboratory of Medical Neurobiology, Department of Neurobiology, Institutes of Brain Science, School of Basic Medical Sciences and Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Hongying ShaState Key Laboratory of Medical Neurobiology, Department of Neurobiology, Institutes of Brain Science, School of Basic Medical Sciences and Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: shahongying@fudan.edu.cn.
Dongmei JiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Hospital Affiliated for Anhui Medical University, Hefei 230022, China.
Helen L ZhangDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Dawei ChenCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Hospital Affiliated for Anhui Medical University, Hefei 230022, China.
Yunxia CaoCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Hospital Affiliated for Anhui Medical University, Hefei 230022, China.
Jianhong ZhuState Key Laboratory of Medical Neurobiology, Department of Neurobiology, Institutes of Brain Science, School of Basic Medical Sciences and Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: jzhu@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inherited mtDNA diseases transmit maternally and cause severe phenotypes. Currently, there is no effective therapy or genetic screens for these diseases; however, nuclear genome transfer between patients' and healthy eggs to replace mutant mtDNAs holds promises. Considering that a polar body contains few mitochondria and shares the same genomic material as an oocyte, we perform polar body transfer to prevent the transmission of mtDNA variants. We compare the effects of different types of germline genome transfer, including spindle-chromosome transfer, pronuclear transfer, and first and second polar body transfer, in mice. Reconstructed embryos support normal fertilization and produce live offspring. Importantly, genetic analysis confirms that the F1 generation from polar body transfer possesses minimal donor mtDNA carryover compared to the F1 generation from other procedures. Moreover, the mtDNA genotype remains stable in F2 progeny after polar body transfer. Our preclinical model demonstrates polar body transfer has great potential to prevent inherited mtDNA diseases.

Indexed as

Nuclear Transfer TechniquesAnimalsHumansMiceMitochondrial DiseasesModels, AnimalOocytesPolar BodiesSpindle Apparatus

Identifiers

PMID24949971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.