Evidence map›Paper›PMID 24949871›Full record

ArticlePloS one2014

Self-reported parental exposure to pesticide during pregnancy and birth outcomes: the MecoExpo cohort study.

Flora Mayhoub, Thierry Berton, Véronique Bach, Karine Tack, Caroline Deguines, Adeline Floch-Barneaud, Sophie Desmots, Erwan Stéphan-Blanchard, Karen Chardon

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02899819 (MecoExpo Study Protocol), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02899819 nacompletednot on this map

MecoExpo Study Protocol

TypeinterventionalSponsorCentre Hospitalier Universitaire, AmiensRan2011 to 2015Enrolled1,020ConditionsInfant, NewbornArmsmeconium
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pesticides and Child's Health in France.Current environmental health reports · 2018
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Flora MayhoubLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Faculty of Medicine, Tishreen University, Latakia, Syria.
Thierry BertonLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Unité NOVA, Institut National de l'Environnement Industriel et des Risques, Verneuil en Halatte, France.
Véronique BachLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France.
Karine TackUnité NOVA, Institut National de l'Environnement Industriel et des Risques, Verneuil en Halatte, France.
Caroline DeguinesLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Médecine Néonatale, Pôle Femme-Couple-Enfant, Centre Hospitalier Universitaire d'Amiens, Amiens, France.
Adeline Floch-BarneaudLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Unité ISAE, Institut National de l'Environnement Industriel et des Risques, Verneuil en Halatte, France.
Sophie DesmotsLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France; Unité TOXI, Institut National de l'Environnement Industriel et des Risques, Verneuil en Halatte, France.
Erwan Stéphan-BlanchardLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France.
Karen ChardonLaboratoire PériTox, Unité mixte Université - INERIS (EA 4285-UMI 01), Université de Picardie Jules Verne, Amiens, France.
Institut national de l'environnement industriel et des risques · FRPérinatalité & Risques Toxiques · FRUniversité de Picardie Jules Verne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The MecoExpo study was performed in the Picardy region of northern France, in order to investigate the putative relationship between parental exposures to pesticides (as reported by the mother) on one hand and neonatal parameters on the other. The cohort comprised 993 mother-newborn pairs. Each mother completed a questionnaire that probed occupational, domestic, environmental and dietary sources of parental exposure to pesticides during her pregnancy. Multivariate regression analyses were then used to test for associations between the characteristics of parental pesticide exposure during pregnancy and the corresponding birth outcomes. Maternal occupational exposure was associated with an elevated risk of low birth weight (odds ratio (OR) [95% confidence interval]: 4.2 [1.2, 15.4]). Paternal occupational exposure to pesticides was associated with a lower than average gestational age at birth (-0.7 weeks; p = 0.0002) and an elevated risk of prematurity (OR: 3.7 [1.4, 9.7]). Levels of domestic exposure to veterinary antiparasitics and to pesticides for indoor plants were both associated with a low birth weight (-70 g; p = 0.02 and -160 g; p = 0.005, respectively). Babies born to women living in urban areas had a lower birth length and a higher risk of low birth length (-0.4 cm, p = 0.006 and OR: 2.9 [1.5, 5.5], respectively). The present study results mainly demonstrate a negative correlation between fetal development on one hand and parental occupational and domestic exposure to pesticides on the other. Our study highlights the need to perform a global and detailed screening of all potential physiological effects when assessing in utero exposure to pesticides.

Indexed as

Occupational ExposurePregnancy OutcomeBirth WeightCohort StudiesFemaleHumansInfantInfant, NewbornMaleParturitionPesticidesPregnancySurveys and QuestionnairesPesticides

Identifiers

PMID24949871
PMCPMC4064975
OpenAlexW2092532167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.