ArticleJournal of biomedical optics2014
Fourier ptychographic microscopy for filtration-based circulating tumor cell enumeration and analysis.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 102 citations in OpenAlex.
- Fast full-color pathological imaging via an optimized illumination pattern with color transfer in Fourier ptychographic microscopy (OIP-CTFPM).Biomedical optics express · 2026Article
- Automated Analysis of Liquid Biopsy Using Deep Learning: Detecting Circulating Tumor Cells and Cancer-Associated Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Fourier ptychography microscopy for digital pathology.Journal of microscopy · 2025Review
- Deep-ultraviolet Fourier ptychography (DUV-FP) for label-free biochemical imaging via feature-domain optimization.APL photonics · 2024Article
- Spatially-coded Fourier ptychography: flexible and detachable coded thin films for quantitative phase imaging with uniform phase transfer characteristics.Advanced optical materials · 2024Article
- Review
- Fast Fourier ptychographic quantitative phase microscopy for in vitro label-free imaging.Biomedical optics express · 2024Article
- Spatial- and Fourier-domain ptychography for high-throughput bio-imaging.Nature protocols · 2023Review
- Automatic detection of circulating tumor cells and cancer associated fibroblasts using deep learning.Scientific reports · 2023Article
- Optical ptychography for biomedical imaging: recent progress and future directions [Invited].Biomedical optics express · 2023Review
- Beyond conventional microscopy: Observing kidney tissues by means of fourier ptychography.Frontiers in physiology · 2023Article
- Article
- Robust Fourier ptychographic microscopy via a physics-based defocusing strategy for calibrating angle-varied LED illumination.Biomedical optics express · 2022Article
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Article
- Wide-field Fourier ptychographic microscopy using laser illumination source.Biomedical optics express · 2016Article
- Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy.Biomedical optics express · 2016Article
- Wide field-of-view fluorescence image deconvolution with aberration-estimation from Fourier ptychography.Biomedical optics express · 2016Article
- Errata: Fourier ptychographic microscopy for filtration-based circulating tumor cell enumeration and analysis.Journal of biomedical optics · 2015Article
- Digital micromirror device-based laser-illumination Fourier ptychographic microscopy.Optics express · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Circulating tumor cells (CTCs) are recognized as a candidate biomarker with strong prognostic and predictive potential in metastatic disease. Filtration-based enrichment technologies have been used for CTC characterization, and our group has previously developed a membrane microfilter device that demonstrates efficacy in model systems and clinical blood samples. However, uneven filtration surfaces make the use of standard microscopic techniques a difficult task, limiting the performance of automated imaging using commercially available technologies. Here, we report the use of Fourier ptychographic microscopy (FPM) to tackle this challenge. Employing this method, we were able to obtain high-resolution color images, including amplitude and phase, of the microfilter samples over large areas. FPM's ability to perform digital refocusing on complex images is particularly useful in this setting as, in contrast to other imaging platforms, we can focus samples on multiple focal planes within the same frame despite surface unevenness. In model systems, FPM demonstrates high image quality, efficiency, and consistency in detection of tumor cells when comparing corresponding microfilter samples to standard microscopy with high correlation (R² = 0.99932). Based on these results, we believe that FPM will have important implications for improved, high throughput, filtration-based CTC analysis, and, more generally, image analysis of uneven surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.