ArticleBehavioural pharmacology2014
Eating high fat chow and the behavioral effects of direct-acting and indirect-acting dopamine receptor agonists in female rats.
Article in Behavioural pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Eating a ketogenic diet enhances sensitivity of rats to the effects of methamphetamine, but not dopamine DPharmacology, biochemistry, and behavior · 2025Article
- Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.Pharmacological reviews · 2021Review
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- The Effects of Eating a High Fat Diet on Sensitivity of Male and Female Rats to Methamphetamine and Dopamine DThe Journal of pharmacology and experimental therapeutics · 2020Article
- Dietary supplementation with fish oil reverses high fat diet-induced enhanced sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2019Article
- Functional and structural plasticity contributing to obesity: roles for sex, diet, and individual susceptibility.Current opinion in behavioral sciences · 2018Article
- Dietary influences on cognition.Physiology & behavior · 2018Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2017Article
- Comparison of cocaine reinforcement in lean and obese Zucker rats: Relative potency and reinstatement of extinguished operant responding.Physiology & behavior · 2017Article
- High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling.ACS chemical neuroscience · 2017Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats.Drug and alcohol dependence · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Eating high fat chow increases the sensitivity of male rats to some behavioral effects of the direct-acting dopamine receptor agonist quinpirole; it is not known whether sensitivity to quinpirole is similarly enhanced in female rats eating high fat chow. Female Sprague-Dawley rats had free access to standard chow (5.7% fat) or either free or restricted access (i.e. body weight matched to rats eating standard chow) to high fat (34.3% fat) chow. Quinpirole (0.0032-0.32 mg/kg) produced hypothermia and a low frequency of yawning. Eating high fat chow produced insulin resistance without affecting quinpirole-induced yawning or hypothermia. Pretreatment with the dopamine D2 receptor antagonist L-741,626 failed to increase quinpirole-induced yawning, indicating that the low frequency of yawning was not due to enhanced D2 receptor sensitivity. Compared with younger (postnatal day 75), drug-naive female rats in a previous study, rats in the present study (postnatal day 275) were more sensitive to cocaine-elicited (1-17.8 mg/kg) locomotion and the development of sensitization across 5 weeks; however, eating high fat chow did not further enhance these effects. These results suggest that drug history and age might modulate the effects of diet on sensitivity to drugs acting on dopamine systems.
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