ArticleJournal of the American Chemical Society2014
Carboxylated glucuronic poly-amido-saccharides as protein stabilizing agents.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- Clickable polyamidosaccharides: accessing bottlebrush inspired hyaluronic acid glycopolymers for CD44 targeting of breast cancer cells.Biomaterials science · 2026Article
- Synthesis of Amphiphilic Amino Poly-Amido-Saccharide and Poly(lactic) Acid Block Copolymers and Fabrication of Paclitaxel-Loaded Mucoadhesive Nanoparticles.Bioconjugate chemistry · 2024Article
- Radical Ring Opening Polymerization of Cyclic Ketene Acetals Derived From d-Glucal.ACS macro letters · 2023Article
- Synthesis and characterization of carbohydrate-based biosurfactant mimetics.Carbohydrate research · 2022Article
- Beyond nylon 6: polyamidesChemical Society reviews · 2022Review
- Sulfated poly-amido-saccharides (sulPASs) are anticoagulantsChemical science · 2021Article
- Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the Pore-Forming Activity of Nylon-3 Polymers.Journal of the American Chemical Society · 2021Article
- A Synthetic Bioinspired Carbohydrate Polymer with Mucoadhesive Properties.Angewandte Chemie (International ed. in English) · 2020Article
- Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization.Macromolecular rapid communications · 2018Article
- Substituted Polyesters by Thiol-Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization.Journal of the American Chemical Society · 2017Article
- Synthetic Biomaterials from Metabolically Derived Synthons.Chemical reviews · 2016Review
- Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The synthesis of novel carbohydrate-based polymers allows the structure to be tailored at the monomer level for a specific property and expands the range of available structures beyond those found in nature. Using a controlled anionic polymerization, a new type of carbohydrate polymer is synthesized in which glucose-derived monomers are joined by an α-1,2 amide linkage to give enantiopure poly-amido-saccharides (PASs). To investigate the effect of adding ionizable carboxylic acid groups, such as those found in natural polysaccharides containing glucuronic acid, the oxidation of the primary alcohol at the C6-position of the repeat unit to a carboxylic acid is reported. TEMPO-mediated oxidation provides control over the degree of oxidation in excellent yield. Based on circular dichroism, the oxidized polymers possess an ordered helical secondary structure in aqueous solution. Finally, oxidized PASs stabilize lysozyme toward dehydration and freezing stresses better than a current, widely used protein stabilizing agent, trehalose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.