ArticleBioMed research international2014
Circadian modulation of the Cl(-) equilibrium potential in the rat suprachiasmatic nuclei.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- GABAProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Circadian Rhythm Regulation by Pacemaker Neuron Chloride Oscillation in Flies.Physiology (Bethesda, Md.) · 2024Review
- Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade.Current biology : CB · 2022Article
- Long-Term Imaging Reveals a Circadian Rhythm of Intracellular Chloride in Neurons of the Suprachiasmatic Nucleus.Journal of biological rhythms · 2022Article
- Modelling the functional roles of synaptic and extra-synaptic γ-aminobutyric acid receptor dynamics in circadian timekeeping.Journal of the Royal Society, Interface · 2021Article
- Role of the cation-chloride-cotransporters in the circadian system.Asian journal of pharmaceutical sciences · 2021Review
- Diurnal properties of tonic and synaptic GABAJournal of neurophysiology · 2021Article
- Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.Physiological reviews · 2020Review
- Astrocytic Modulation of Neuronal Activity in the Suprachiasmatic Nucleus: Insights from Mathematical Modeling.Journal of biological rhythms · 2020Article
- The Excitatory Effects of GABA within the Suprachiasmatic Nucleus: Regulation of Na-K-2Cl Cotransporters (NKCCs) by Environmental Lighting Conditions.Journal of biological rhythms · 2020Article
- Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus.Journal of biological rhythms · 2018Article
- GABAPflugers Archiv : European journal of physiology · 2018Review
- Intracellular Chloride Regulation in AVP+ and VIP+ Neurons of the Suprachiasmatic Nucleus.Scientific reports · 2017Article
- The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.Frontiers in neuroendocrinology · 2017Review
- Circadian Plasticity of Mammalian Inhibitory Interneurons.Neural plasticity · 2017Review
- Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Collective timekeeping among cells of the master circadian clock.The Journal of endocrinology · 2016Review
- Modulation of spontaneous intracellular Ca²⁺ fluctuations and spontaneous cholinergic transmission in rat chromaffin cells in situ by endogenous GABA acting on GABAA receptors.Pflugers Archiv : European journal of physiology · 2016Article
- The anterior paraventricular thalamus modulates neuronal excitability in the suprachiasmatic nuclei of the rat.The European journal of neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suprachiasmatic nuclei (SCN) constitute a circadian clock in mammals, where γ-amino-butyric acid (GABA) neurotransmission prevails and participates in different aspects of circadian regulation. Evidence suggests that GABA has an excitatory function in the SCN in addition to its typical inhibitory role. To examine this possibility further, we determined the equilibrium potential of GABAergic postsynaptic currents (E(GABA)) at different times of the day and in different regions of the SCN, using either perforated or whole cell patch clamp. Our results indicate that during the day most neurons in the dorsal SCN have an E(GABA) close to -30 mV while in the ventral SCN they have an E(GABA) close to -60 mV; this difference reverses during the night, in the dorsal SCN neurons have an E(GABA) of -60 mV and in the ventral SCN they have an E(GABA) of -30 mV. The depolarized equilibrium potential can be attributed to the activity of the Na(+)-K(+)-2Cl(-) (NKCC) cotransporter since the equilibrium potential becomes more negative following addition of the NKCC blocker bumetanide. Our results suggest an excitatory role for GABA in the SCN and further indicate both time (day versus night) and regional (dorsal versus ventral) modulation of E(GABA) in the SCN.
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