ReviewBioMed research international2014
Substituted hydroxyapatites with antibacterial properties.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 257 citations in OpenAlex.
- Article
- Multifunctional Xanthan Gum-Hydroxyapatite Composite with Enhanced Dye Adsorption, Antibacterial Activity, and Cytocompatibility.Materials (Basel, Switzerland) · 2026Article
- Differential Roles of Ag and ZnO in the Bactericidal Activity of Ag/ZnO-Hydroxyapatite Nanocomposites against Multidrug-Associated Methicillin-Resistant Staphylococcus aureus.Current microbiology · 2026Article
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Synchrotron cryo-soft X-ray microscopy reveals bacterial interactions with nanostructured calcium phosphate substrates.Nature communications · 2026Article
- Synergistic effect of rare-earth and transition metal conversion coatings on bioactive hydroxyapatite mineralization and electrochemical behavior of AZ31 magnesium alloys.Scientific reports · 2026Article
- Physico-Chemical and Biological Evaluation of Spin-Coated Chromium-Doped Hydroxyapatite in Dextran Matrix Coatings.Biomimetics (Basel, Switzerland) · 2026Article
- Designing Multifunctional Antibacterial Hydrogels: A Tri-Pillar Approach Based on Bacteriophages, Hydroxyapatite, and Electrospun Systems.Gels (Basel, Switzerland) · 2026Review
- Nanostructured Sr-Doped Hydroxyapatite: A Material with Antimicrobial Potential.Nanomaterials (Basel, Switzerland) · 2025Article
- Inhibitory Effect of Allyl Isothiocyanate on Cariogenicity ofInternational journal of molecular sciences · 2025Article
- Assessment of Quality in Antimicrobial Calcium Phosphate Research (AQUACAP): A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- Bacterial colonization of bone substitute materials used in oral surgery: mechanisms, clinical implications, and preventive strategies-A narrative review.Frontiers in microbiology · 2025Review
- Application of Nanohydroxyapatite in Medicine-A Narrative Review.Molecules (Basel, Switzerland) · 2024Review
- Correlation between biomedical and structural properties of Zn/Sr modified calcium phosphates.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Dental Applications of Ion-Substituted Hydroxyapatite: A Review of the Literature.Dentistry journal · 2024Review
- Synthesis and Antimicrobial Analysis of High Surface Area Strontium-Substituted Calcium Phosphate Nanostructures for Bone Regeneration.International journal of molecular sciences · 2023Article
- Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection againstMaterials (Basel, Switzerland) · 2023Article
- Inhibitory Effect of Adsorption ofInternational journal of molecular sciences · 2023Article
- Review
- Construction of ZnO/PCL Antibacterial Coating Potentially for Dental Unit Waterlines.Journal of functional biomaterials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.