Evidence map›Paper›PMID 24949416›Full record

Trial reportBioMed research international2014

Quantifying cerebellum grey matter and white matter perfusion using pulsed arterial spin labeling.

Xiufeng Li, Subhendra N Sarkar, David E Purdy, Richard W Briggs

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. DynamicMagnetic resonance in medicine · 2022
    Article
  5. Giant central nervous system tuberculoma in pediatric patients: surgical case series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiufeng LiDepartment of Radiology and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, MN 55455, USA.
Subhendra N SarkarDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
David E PurdySiemens Healthcare, Malvern, PA 19355, USA.
Richard W BriggsDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA ; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA ; Department of Physics & Astronomy, Georgia State University, Atlanta, GA 30302, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)KL2TR000113 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$5.4M
NCATS NIH HHS KL2 TR000113NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1TR000114
6 · The paper itself

Abstract

To facilitate quantification of cerebellum cerebral blood flow (CBF), studies were performed to systematically optimize arterial spin labeling (ASL) parameters for measuring cerebellum perfusion, segment cerebellum to obtain separate CBF values for grey matter (GM) and white matter (WM), and compare FAIR ASST to PICORE. Cerebellum GM and WM CBF were measured with optimized ASL parameters using FAIR ASST and PICORE in five subjects. Influence of volume averaging in voxels on cerebellar grey and white matter boundaries was minimized by high-probability threshold masks. Cerebellar CBF values determined by FAIR ASST were 43.8 ± 5.1 mL/100 g/min for GM and 27.6 ± 4.5 mL/100 g/min for WM. Quantitative perfusion studies indicated that CBF in cerebellum GM is 1.6 times greater than that in cerebellum WM. Compared to PICORE, FAIR ASST produced similar CBF estimations but less subtraction error and lower temporal, spatial, and intersubject variability. These are important advantages for detecting group and/or condition differences in CBF values.

Indexed as

CerebellumSpin LabelsAdultBlood Flow VelocityCerebral ArteriesCerebrovascular CirculationHumansMagnetic Resonance AngiographyMalePulsatile FlowRadiographySpin Labels

Identifiers

PMID24949416
PMCPMC4052111

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.