ArticlePakistan journal of medical sciences2014
Vascular Endothelial Growth Factor expression in peripheral blood of patients with pregnancy induced hypertension syndrome and its clinical significance.
Article in Pakistan journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Data-Driven Stratification Reveals 3 Distinct Clinicopathologic Phenotypes in Renal Thrombotic Microangiopathy.Mayo Clinic proceedings. Digital health · 2026Article
- Genetic Variations in Vascular Endothelial Growth Factor and Their Impact on Preeclampsia: Insights into Risk, Severity, and Pregnancy Outcomes.Current issues in molecular biology · 2025Review
- Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure: A Systematic Review.Journal of clinical medicine · 2023Review
- A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2.International journal of molecular sciences · 2023Review
- Combined Effects of Methyldopa and Baicalein orPharmaceuticals (Basel, Switzerland) · 2022Article
- Melatonin ameliorates hypertension in hypertensive pregnant mice and suppresses the hypertension-induced decrease in CaHypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Combined Effects of Methyldopa and Flavonoids on the Expression of Selected Factors Related to Inflammatory Processes and Vascular Diseases in Human Placenta Cells-An In Vitro Study.Molecules (Basel, Switzerland) · 2021Article
- Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor.Lipids in health and disease · 2020Article
- VEGF and sFLT-1 in serum of PIH patients and effects on the foetus.Experimental and therapeutic medicine · 2019Article
- Therapeutic Effect of Long-Term Epidural Block in Rats with Pregnancy Induced Hypertension.BioMed research international · 2018Article
- Magnesium Sulfate in combination with Nifedipine in the treatment of Pregnancy-Induced Hypertension.Pakistan journal of medical sciencesArticle
- Pregnancy-induced hypertension awareness, knowledge and its risk factors: A cross-sectional study.Pakistan journal of medical sciencesArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was conducted was to detect vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) syndrome and to investigate VEGF correlation with PIH occurrence.
methodsDouble-antibody enzyme-linked immunosorbent assay and fluorescent quantitative polymerase chain reaction were used to detect VEGF levels in the peripheral blood of non-pregnant women (normal group, 30 cases), normal pregnant women (pregnancy group, 30 cases) and PIH patients (PIH group, 30 cases).
resultsVEGF level in the pregnancy group was significantly higher than in the normal group, and the difference between these two groups was significant (P < 0.001). In the pregnancy group, VEGF reached the maximum level at the metaphase stage of pregnancy and started to decrease at advanced pregnancy. VEGF level in the PIH group was significantly lower than in the pregnancy group at advanced pregnancy (P < 0.01), and VEGF level significantly and gradually decreased with PIH aggravation (P < 0.05).
conclusionsThe significant decrease of VEGF level after pregnancy was possibly an important factor of PIH pathogenesis.
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