ArticleNanoscale research letters2014
Mechanical characteristics of mesenchymal stem cells under impact of silica-based nanoparticles.
Article in Nanoscale research letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Article
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- Transient cell stiffening triggered by magnetic nanoparticle exposure.Journal of nanobiotechnology · 2021Article
- Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins.Nanomaterials (Basel, Switzerland) · 2020Article
- Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices.Nanotechnology · 2020Review
- Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles.Frontiers in physiology · 2019Article
- The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.Lab on a chip · 2016Article
- Acute Hypoxic Stress Affects Migration Machinery of Tissue OStem cells international · 2016Article
- Investigation of cellular responses upon interaction with silver nanoparticles.International journal of nanomedicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silica-based nanoparticles (NPs) pose great potential for medical and biological applications; however, their interactions with living cells have not been investigated in full. The objective of this study was to analyze the mechanical characteristics of mesenchymal stem cells when cultured in the presence of silica (Si) and silica-boron (SiB) nanoparticles. Cell stiffness was measured using atomic force microscopy; F-actin structure was evaluated using TRITC-phalloidin by confocal microscopy. The obtained data suggested that the cell stiffness increased within the following line: 'Control' - 'Si' - 'SiB' (either after 1-h cultivation or 24-h incubation). Moreover, the cell stiffness was found to be higher after 1-h cultivation as compared to 24-h cultivation. This result shows that there is a two-phase process of particle diffusion into cells and that the particles interact directly with the membrane and, further, with the submembranous cytoskeleton. Conversely, the intensity of phalloidin fluorescence dropped within the same line: Control - Si - SiB. It could be suggested that the effects of silica-based particles may result in structural reorganization of cortical cytoskeleton with subsequent stiffness increase and concomitant F-actin content decrease (for example, in recruitment of additional actin-binding proteins within membrane and regrouping of actin filaments).
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Registered trials
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