ReviewInternational journal of biological sciences2014
Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment.
Review in International journal of biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Synthesis, Molecular Modeling and Assessment of Anticancer Activity of New Potential CYP17A1 Inhibitors.Molecules (Basel, Switzerland) · 2026Article
- Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment.Journal of medicinal chemistry · 2023Review
- Serum Androgen Metabolites Correlate with Clinical Variables in African and European American Men with Localized, Therapy Naïve Prostate Cancer.Metabolites · 2023Article
- Non-Classic Disorder of Adrenal Steroidogenesis and Clinical Dilemmas in 21-Hydroxylase Deficiency Combined with Backdoor Androgen Pathway. Mini-Review and Case Report.International journal of molecular sciences · 2020Review
- Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after castration.Molecular and cellular endocrinology · 2019Article
- Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.Asian journal of urology · 2019Review
- Androgen Signaling in Prostate Cancer.Cold Spring Harbor perspectives in medicine · 2017Review
- Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer.Oncotarget · 2016Review
- Article
- Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-Reductase Inhibition in Prostate Epithelial Cells.The Journal of biological chemistry · 2016Article
- Antineoplastic Isoflavonoids Derived from Intermediate ortho-Quinone Methides Generated from Mannich Bases.ChemMedChem · 2016Article
- Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Androgen-glucocorticoid interactions in the era of novel prostate cancer therapy.Nature reviews. Urology · 2016Review
- Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents.Organic & biomolecular chemistry · 2015Article
- A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.Cancer medicine · 2015Article
- Biological and clinical significance of androgens and androgen receptor in prostate cancer.International journal of biological sciences · 2014Article
- Alpha Thalassemia/Intellectual Disability Syndrome X-Linked Expression Varies Significantly between Androgen Receptor-Positive and Androgen Receptor-Negative Prostatic Adenocarcinoma: Relation to Epidermal Growth Factor Receptor Expression and Clinicopathological Factors.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.
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Registered trials
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