ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Foreclosure, memory decline, and dementia probability: A longitudinal cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2024Review
- Leadership in Education, Medical Education and Health.International journal of environmental research and public health · 2022Article
- Corticosterone and Glucocorticoid Receptor in the Cortex of Rats during Aging-The Effects of Long-Term Food Restriction.Nutrients · 2021Article
- Evidence for Similar Prefrontal Structural and Functional Alterations in Male and Female Rats Following Chronic Stress or Glucocorticoid Exposure.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Glucocorticoid Signaling and the Aging Heart.Frontiers in endocrinology · 2020Review
- Structural and molecular correlates of cognitive aging in the rat.Scientific reports · 2019Article
- Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.Brain structure & function · 2018Article
- Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts.Neuroscience and biobehavioral reviews · 2018Review
- Stress-induced corticosterone secretion covaries with working memory in aging.Neurobiology of aging · 2018Article
- Intra-hippocampal D-cycloserine rescues decreased social memory, spatial learning reversal, and synaptophysin levels in aged rats.Psychopharmacology · 2018Article
- Structural racism in the workplace: Does perception matter for health inequalities?Social science & medicine (1982) · 2018Article
- Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling.Frontiers in aging neuroscience · 2018Article
- Running wheel exercise reduces renewal of extinguished instrumental behavior and alters medial prefrontal cortex neurons in adolescent, but not adult, rats.Behavioral neuroscience · 2017Article
- Perceived and post-traumatic stress are associated with decreased learning, memory, and fluency in HIV-infected women.AIDS (London, England) · 2017Article
- γ-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis.Cell reports · 2017Article
- Prolonged corticosterone exposure induces dendritic spine remodeling and attrition in the rat medial prefrontal cortex.The Journal of comparative neurology · 2016Article
- Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice.Neuroscience · 2016Article
- Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders.Neuroscience and biobehavioral reviews · 2015Review
- Worries about getting Alzheimer's: who's concerned?American journal of Alzheimer's disease and other dementias · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive decline in aging is marked by considerable variability, with some individuals experiencing significant impairments and others retaining intact functioning. Whereas previous studies have linked elevated hypothalamo-pituitary-adrenal (HPA) axis activity with impaired hippocampal function during aging, the idea has languished regarding whether such differences may underlie the deterioration of other cognitive functions. Here we investigate whether endogenous differences in HPA activity are predictive of age-related impairments in prefrontal structural and behavioral plasticity. Young and aged rats (4 and 21 months, respectively) were partitioned into low or high HPA activity, based upon averaged values of corticosterone release from each animal obtained from repeated sampling across a 24 h period. Pyramidal neurons in the prelimbic area of medial prefrontal cortex were selected for intracellular dye filling, followed by 3D imaging and analysis of dendritic spine morphometry. Aged animals displayed dendritic spine loss and altered geometric characteristics; however, these decrements were largely accounted for by the subgroup bearing elevated corticosterone. Moreover, high adrenocortical activity in aging was associated with downward shifts in frequency distributions for spine head diameter and length, whereas aged animals with low corticosterone showed an upward shift in these indices. Follow-up behavioral experiments revealed that age-related spatial working memory deficits were exacerbated by increased HPA activity. By contrast, variations in HPA activity in young animals failed to impact structural or behavioral plasticity. These data implicate the cumulative exposure to glucocorticoids as a central underlying process in age-related prefrontal impairment and define synaptic features accounting for different trajectories in age-related cognitive function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.