ArticleThe Journal of experimental biology2014
Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster.
Article in The Journal of experimental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Progressive behavioral and cognitive decline inbioRxiv : the preprint server for biology · 2026Article
- Nutrient Deprivation inInternational journal of molecular sciences · 2026Article
- Metaplastic neuronal state transition regulates species-specific interoceptive processing inbioRxiv : the preprint server for biology · 2026Article
- Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025Article
- Nutritional stress in larvae induces adaptive responses that transcend generations in males of a model insect.The Journal of experimental biology · 2025Article
- Elevated sleep quota in a stress-resilient Drosophila species.Current biology : CB · 2024Article
- Starvation selection reduces and delays larval ecdysone production and signaling.The Journal of experimental biology · 2023Article
- Motus Vita Est: Fruit Flies Need to Be More Active and Sleep Less to Adapt to Either a Longer or Harder Life.Clocks & sleep · 2023Article
- Article
- Loss of neurexin-1 in Drosophila melanogaster results in altered energy metabolism and increased seizure susceptibility.Human molecular genetics · 2022Article
- Expression of a constitutively active insulin receptor in Drosulfakinin (Dsk) neurons regulates metabolism and sleep inBiochemistry and biophysics reports · 2022Article
- Anesthetic Preconditioning of Traumatic Brain Injury Is Ineffective in a Drosophila Model of Obesity.The Journal of pharmacology and experimental therapeutics · 2022Article
- Sleep correlates with behavioral decision making critical for reproductive output in Drosophila melanogaster.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2022Article
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.G3 (Bethesda, Md.) · 2021Article
- Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.Sleep · 2021Article
- Yeast volatiles double starvation survival inScience advances · 2021Article
- Phenotypic coupling of sleep and starvation resistance evolves in D. melanogaster.BMC evolutionary biology · 2020Article
- Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila.PLoS biology · 2020Article
- Eat, sleep, repeat: the role of the circadian system in balancing sleep-wake control with metabolic need.Current opinion in physiology · 2020Review
- Starvation tolerance associated with prolonged sleep bouts upon starvation in a single natural population of Drosophila melanogaster.Journal of evolutionary biology · 2019Article
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Authors and funding
9 authors.
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Abstract
Animals respond to changes in food availability by adjusting sleep and foraging strategies to optimize their fitness. Wild populations of the fruit fly, Drosophila melanogaster, display highly variable levels of starvation resistance that are dependent on geographic location, food availability and evolutionary history. How behaviors that include sleep and feeding vary in Drosophila with increased starvation resistance is unclear. We have generated starvation-resistant flies through experimental evolution to investigate the relationship between foraging behaviors and starvation resistance. Outbred populations of D. melanogaster were selected for starvation resistance over 60 generations. This selection process resulted in flies with a threefold increase in total lipids that survive up to 18 days without food. We tested starvation-selected (S) flies for sleep and feeding behaviors to determine the effect that selection for starvation resistance has had on foraging behavior. Flies from three replicated starvation-selected populations displayed a dramatic reduction in feeding and prolonged sleep duration compared to fed control (F) populations, suggesting that modified sleep and feeding may contribute to starvation resistance. A prolonged larval developmental period contributes to the elevated energy stores present in starvation-selected flies. By preventing S larvae from feeding longer than F larvae, we were able to reduce energy stores in adult S flies to the levels seen in adult F flies, thus allowing us to control for energy storage levels. However, the reduction of energy stores in S flies fails to generate normal sleep and feeding behavior seen in F flies with similar energy stores. These findings suggest that the behavioral changes observed in S flies are due to genetic regulation of behavior rather than elevated lipid levels. Testing S-F hybrid individuals for both feeding and sleep revealed a lack of correlation between food consumption and sleep duration, indicating further independence in genetic factors underlying the sleep and feeding changes observed in S flies. Taken together, these findings provide evidence that starvation selection results in prolonged sleep and reduced feeding through a mechanism that is independent of elevated energy stores. These findings suggest that changes in both metabolic function and behavior contribute to the increase in starvation resistance seen in flies selected for starvation resistance.
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