ArticlePlant cell reports2014
Myb14, a direct activator of STS, is associated with resveratrol content variation in berry skin in two grape cultivars.
Article in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Studies on the Role and Function of miR3630-5p-VqNAC92-VqMYB14/VqRAP2.12-VqSTSs in Vitis quinquangularis Plant Immunity.Plant, cell & environment · 2026Article
- Integrated Metabolomics and Transcriptomics Provided Novel Insights into the Biosynthetic Regulation of Phenolic Compounds inFoods (Basel, Switzerland) · 2026Article
- Research progress on the biosynthesis and regulatory mechanisms of resveratrol in plants.Frontiers in plant science · 2026Review
- VqERF1B-VqERF062-VqNSTS2 transcriptional cascade enhances stilbene biosynthesis and resistance to powdery mildew in grapevine.Plant biotechnology journal · 2025Article
- Advances in understanding cold tolerance in grapevine.Plant physiology · 2023Review
- VqMAPK3/VqMAPK6, VqWRKY33, andHorticulture research · 2023Article
- Genome-wide characterization and functional identification ofFrontiers in plant science · 2023Article
- Effect ofPlants (Basel, Switzerland) · 2022Article
- Effect of Calmodulin-like Gene (Plants (Basel, Switzerland) · 2022Article
- VqMYB154 promotes polygene expression and enhances resistance to pathogens in Chinese wild grapevine.Horticulture research · 2021Article
- Role of Resveratrol in Regulating Cutaneous Functions.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Molecular Analysis of UV-C Induced Resveratrol Accumulation inInternational journal of molecular sciences · 2019Article
- Transcription factor VqERF114 regulates stilbene synthesis in Chinese wild Vitis quinquangularis by interacting with VqMYB35.Plant cell reports · 2019Article
- Transcriptional regulation of stilbene synthases in grapevine germplasm differentially susceptible to downy mildew.BMC plant biology · 2019Article
- Article
- VvWRKY8 represses stilbene synthase genes through direct interaction with VvMYB14 to control resveratrol biosynthesis in grapevine.Journal of experimental botany · 2019Article
- Regulation of stilbene biosynthesis in plants.Planta · 2017Review
- Factor Analysis of MYB Gene Expression and Flavonoid Affecting Petal Color in Three Crabapple Cultivars.Frontiers in plant science · 2017Article
- Insights into the Mechanisms Underlying Ultraviolet-C Induced Resveratrol Metabolism in Grapevine (V. amurensis Rupr.) cv. "Tonghua-3".Frontiers in plant science · 2016Article
- Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants.Planta · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageHigh and low resveratrol (Res) contents in two cultivars are correlated with the expression abundance of Myb14 , which could directly activate transcriptional expression of stilbene synthase gene ( STS ). Resveratrol (3,5,4'-trihydroxystilbene) is one of the natural polyphenols produced by secondary metabolism in some plants. Stilbene synthase (STS) is the key enzyme for the final step of precursor formation of resveratrol (Res) in grapevines. In this study, we found that Res contents in ripe berry skin were completely different in two grape cultivars, namely, 'Z168' (Vitis monticola × Vitis riparia) with high-Res and 'Jingzaojing' (Vitis vinifera) with low-Res. Moreover, the level of expression of STS gene was higher in the ripe berry skin of 'Z168' than in that of 'Jingzaojing'. To further investigate the underlying mechanisms, we conducted a co-expression analysis through transcriptomic data. We confirmed that Myb14, an R2R3 Myb transcription factor, is the direct regulator of STS by binding to Box-L5 motif. Moreover, the expression pattern of Myb14 is associated with the variation of Res content. To test this prediction, we conducted a number of experiments in vivo and in vitro. The expression patterns of Myb14 and STS in grapevine leaves were identical under a series of stimulus. Myb14 showed higher expression in the ripe berry skin of 'Z168' than in that of 'Jingzaojing'. Yeast one-hybrid assay indicated that grapevine Myb14 could interact with the promoter of STS in vitro, and the transient overexpression of Myb14 promoted the expression of STS. Furthermore, co-expressing 35S::Myb14 in transgenic Arabidopsis could activate GUS expression promoted by STS promoter. Thus, Myb14 is the direct activator of STS, and its expression pattern is associated with Res content variation in grapes.
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