ArticleAJNR. American journal of neuroradiology2014
MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
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- Clinical applicability of miR517a detection in liquid biopsies of ETMR patients.Acta neuropathologica · 2023Article
- Embryonal Tumors of the Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors.Advances in experimental medicine and biology · 2023Article
- 2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist.Neuroradiology · 2022Review
- Embryonal tumor with multilayered rosettes in a teenager.Autopsy & case reports · 2022Article
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- Case report: Ventricular primary central nervous system lymphoma with partial hypointensity on diffusion-weighted imaging.Frontiers in neurology · 2022Article
- Embryonal tumors with multilayered rosettes,Frontiers in oncology · 2022Article
- Ependymoblastoma with pulmonary metastasis in an adolescent: A case report.Frontiers in neurology · 2022Article
- Intradural Pediatric Spinal Tumors: An Overview from Imaging to Novel Molecular Findings.Diagnostics (Basel, Switzerland) · 2021Review
- Malignant Ependymoblastoma Mimicking a Benign Pilocytic Astrocytoma.Neurology international · 2020Article
- ETMR: a tumor entity in its infancy.Acta neuropathologica · 2020Review
- CT and Multimodal MR Imaging Features of Embryonal Tumors with Multilayered Rosettes in Children.AJNR. American journal of neuroradiology · 2019Article
- Clinical and magnetic resonance imaging findings of a cerebellar medulloblastoma in a heifer.Clinical case reports · 2019Article
- A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.Nature medicine · 2017Article
- Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified.Neuro-oncology · 2015Article
- Freiburg Neuropathology Case Conference: An Infant with a Supratentorial Mass Lesion.Clinical neuroradiology · 2015Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeEpendymoblastoma is a malignant embryonal tumor that develops in early childhood and has a dismal prognosis. Categorized by the World Health Organization as a subgroup of CNS-primitive neuroectodermal tumor, ependymoblastoma is histologically defined by "ependymoblastic rosettes." Because it is so rare, little is known about specific MR imaging characteristics of ependymoblastoma. We systematically analyzed and discussed MR imaging features of ependymoblastoma in a series of 22 consecutive patients. MATERIALS AND
methodsEpendymoblastoma cases were obtained from the database of the German multicenter HIT trials between 2002 and 2013. All cases within this study were centrally reviewed for histopathology, MR imaging findings, and multimodal therapy. For systematic analysis of initial MR imaging scans at diagnosis, we applied standardized criteria for reference image evaluation of pediatric brain tumors.
resultsEpendymoblastomas are large tumors with well-defined tumor margins, iso- to hyperintense signal on T2WI, and diffusion restriction. Contrast enhancement is variable, with a tendency to mild or moderate enhancement. Subarachnoid spread is common in ependymoblastoma but can be absent initially. There was a male preponderance (1.75:1 ratio) for ependymoblastoma in our cohort. Mean age at diagnosis was 2.1 years.
conclusionsWith this study, we add the largest case collection to the limited published database of MR imaging findings in ependymoblastoma, together with epidemiologic data. However, future studies are needed to systematically compare MR imaging findings of ependymoblastoma with other CNS-primitive neuroectodermal tumors and ependymoma, to delineate imaging criteria that might help distinguish these pediatric brain tumor entities.
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