ArticleParasitology research2014
Markers of oxidative stress in adipose tissue during Trypanosoma cruzi infection.
Article in Parasitology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Adipose Tissue in Chagas Disease: A Neglected Component of Pathogenesis.Pathogens (Basel, Switzerland) · 2025Review
- Adipocyte-released adipomes in Chagas cardiomyopathy: Impact on cardiac metabolic and immune regulation.iScience · 2024Article
- Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens.Frontiers in immunology · 2023Review
- Oxidative stress implications for therapeutic vaccine development against Chagas disease.Expert review of vaccines · 2021Review
- Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth.Cellular microbiology · 2021Article
- Diet Rich in Lard Promotes a Metabolic Environment Favorable toFrontiers in cardiovascular medicine · 2021Article
- Article
- Priming Astrocytes With HIV-Induced Reactive Oxygen Species Enhances TheirFrontiers in microbiology · 2020Article
- Advances in understanding the role of adipose tissue and mitochondrial oxidative stress inF1000Research · 2019Review
- ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart.PLoS pathogens · 2018Review
- Adipose Tissue: A Safe Haven for Parasites?Trends in parasitology · 2017Review
- Anti-apoptotic effects of Sonic hedgehog signalling through oxidative stress reduction in astrocytes co-cultured with excretory-secretory products of larval Angiostrongylus cantonensis.Scientific reports · 2017Article
- Diet regulates liver autophagy differentially in murine acute Trypanosoma cruzi infection.Parasitology research · 2017Article
- Diet Modulates Adipose Tissue Oxidative Stress in a Murine Acute Chagas Model.JSM atherosclerosis · 2017Article
- Article
- Neonatal capsaicin treatment in rats induces chronic hyperthermia resulting in infectious disease.Experimental and therapeutic medicine · 2015Article
- Trypanosoma cruzi burden, genotypes, and clinical evaluation of Chilean patients with chronic Chagas cardiopathy.Parasitology research · 2015Article
- Trypanosoma cruzi infection and benznidazole therapy independently stimulate oxidative status and structural pathological remodeling of the liver tissue in mice.Parasitology research · 2015Article
- The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma cruzi infection in CD-1 mice.Diabetes/metabolism research and reviews · 2015Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The protozoan parasite Trypanosoma cruzi causes Chagas disease. Cardiac and adipose tissues are among the early targets of infection and are sites of persistent infection. In the heart and adipose tissue, T. cruzi infection results in an upregulation of pro-inflammatory mediators. In the heart, infection is associated with an increase in the markers of oxidative stress. To date, markers of oxidative stress have not been evaluated in adipose tissue in this infection. Brown and white adipose tissues were obtained from CD-1 mice infected with the Brazil strain of T. cruzi for 15, 30, and 130 days post infection. Protein carbonylation and lipid peroxidation assays were performed on these samples. There was an upregulation of these markers of oxidative stress at all time-points in both white and brown adipose tissue. Determinants of anti-oxidative stress were downregulated at similar time-points. This increase in oxidative stress during T. cruzi infection most likely has a deleterious effect on host metabolism and on the heart.
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Registered trials
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