Evidence map›Paper›PMID 24947900›Full record

Trial reportRespiratory medicine2014

Obesity and symptoms of depression contribute independently to the poor asthma control of obesity.

S G Kapadia, C Wei, S J Bartlett, J Lang, R A Wise, A E Dixon, American Lung Association Asthma Clinical Research Centers

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Article
  3. Asthma interactions between obesity and other risk factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden.GMS current topics in otorhinolaryngology, head and neck surgery · 2015
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

S G KapadiaUniversity of Vermont College of Medicine, Burlington, VT, USA.
C WeiJohns Hopkins University, Baltimore, MD, USA.
S J BartlettMcGill University, Montreal, Canada.
J LangNemours Children's Hospital, Orlando, FL, USA.
R A WiseJohns Hopkins University, Baltimore, MD, USA.
A E DixonUniversity of Vermont College of Medicine, Burlington, VT, USA. Electronic address: anne.dixon@vtmednet.org.
American Lung Association Asthma Clinical Research Centers
Johns Hopkins University · USUniversity of Vermont · USMcGill University · CANemours Children's Clinic · US

Funding

TRANSLATIONAL RESEARCH IN LUNG BIOLOGY AND DISEASEP30RR031158 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2010 to 2011
$2.6M
The Placebo Effect in AsthmaR01HL073494 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WISE, ROBERT A. · 2002 to 2005
$2.4M
NCRR NIH HHS P30 RR031158NCRR NIH HHS P30 RR031158-01NHLBI NIH HHS R01 HL073494NHLBI NIH HHS R01HL073494
6 · The paper itself

Abstract

unlabelledObesity is a major risk factor for poorly controlled asthma, but the reasons for poor asthma control in this patient population are unclear. Symptoms of depression have been associated with poor asthma control, and increase with higher body mass index (BMI). The purpose of this study was to assess whether depressive symptoms underlie poor asthma control in obesity.

methodsWe determined the relationship between BMI, psychological morbidity and asthma control at baseline in a well-characterized patient population participating in a clinical trial conducted by the American Lung Association-Asthma Clinical Research Centers.

resultsObese asthmatic participants had increased symptoms of depression (Center for Epidemiologic Studies Depression Scale score in lean 10.1 ± 8.1, overweight 10.0 ± 8.1, obese 12.4 ± 9.9; p = 0.03), worse asthma control (Juniper Asthma Control Questionnaire score in lean 1.43 ± 0.68, overweight 1.52 ± 0.71, obese 1.76 ± 0.75; p < 0.0001), and worse asthma quality of life (scores in lean 5.21 ± 1.08, overweight 5.08 ± 1.05, obese 4.64 ± 1.09; p < 0.0001). Asthmatics with obesity and those with symptoms of depression both had a higher risk of having poorly controlled asthma (adjusted odds ratio of 1.83 CI 1.23-3.52 for obesity, and 2.08 CI 1.23-3.52 for depression), but there was no interaction between the two.

conclusionObesity and symptoms of depression are independently associated with poor asthma control. As depression is increased in obese asthmatics it may be an important co-morbidity contributing to poor asthma control in this population, but factors other than depression also contribute to poor asthma control in obesity.

Indexed as

AdultAsthmaBody Mass IndexDepressionFemaleForced Expiratory VolumeHumansMaleObesityOverweightQuality of LifeRisk FactorsThinnessVital CapacityAsthmaDepressionObesity

Identifiers

PMID24947900
PMCPMC4130899
OpenAlexW2060815795

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.