Evidence map›Paper›PMID 24947346›Full record

ArticleObesity surgery2014

Medication cost is significantly reduced after Roux-en-Y gastric bypass in obese patients.

Ina Gesquiere, Judith Aron-Wisnewsky, Veerle Foulon, Steeve Haggege, Bart Van der Schueren, Patrick Augustijns, Jean-Luc Bouillot, Karine Clement, Arnaud Basdevant, Jean-Michel Oppert and 1 more

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In one paragraph

Article in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  12. The utility of weight loss medications after bariatric surgery for weight regain or inadequate weight loss: A multi-center study.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Ina GesquiereDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, O&N II, Herestraat 49, Box 521, 3000, Leuven, Belgium, ina.gesquiere@pharm.kuleuven.be.
Judith Aron-Wisnewsky
Veerle Foulon
Steeve Haggege
Bart Van der Schueren
Patrick Augustijns
Jean-Luc Bouillot
Karine Clement
Arnaud Basdevant
Jean-Michel Oppert
Marion Buyse
Inserm · FRKU Leuven · BEAssistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRUniversitair Ziekenhuis Leuven · BEUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to determine the influence of Roux-en-Y gastric bypass (RYGB) on medication-related costs.

methodsThe study analyzed the types, dosages, and costs of drugs and medical devices prescribed before and after surgery (1, 3, 6, and 12 months and yearly thereafter) in patients who underwent RYGB between June 2004 and May 2010 and had an outpatient visit between December 2009 and May 2010 at Pitié-Salpêtrière University Hospital, Paris, France.

resultsThe cohort included 143 patients (78 % female; mean age, 42.9 years; mean BMI, 48.6 kg/m(2)). Total prescription costs were significantly lower (-32 %, p < 0.001) 1 year after RYGB compared with preoperative costs. However, the cost for medications to prevent RYGB side effects (in particular nutritional deficiencies) displayed a 36-fold increase in the first month postsurgery, but then decreased progressively over time. Importantly, the cost related to the treatment of the two most frequent obesity-related diseases significantly decreased 1 year after surgery. Indeed, prescription costs for treatment of type 2 diabetes (T2D) and obstructive sleep apnea (OSA) (namely CPAP therapy considered as the gold standard treatment) were reduced 1 year after surgery by 85 and by 63 % (both p < 0.001), respectively. We also observed a trend toward a decrease in the prescription costs of other obesity-related diseases, although it did not reach significance in our cohort.

conclusionsConsidering medication to treat both obesity-related diseases and prevention of secondary effects of bariatric surgery, we observed that overall postoperative medication costs were significantly reduced one year after surgery, especially for T2D and OSA.

Indexed as

AdultCost-Benefit AnalysisDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGastric BypassHumansMaleObesity, MorbidParisRetrospective StudiesTreatment Outcome

Identifiers

PMID24947346
OpenAlexW2054985449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.