Evidence map›Paper›PMID 24947321›Full record

ReviewCellular and molecular life sciences : CMLS2014

Tyrosine nitration as mediator of cell death.

María C Franco, Alvaro G Estévez

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 46 citations in OpenAlex.

  1. Oxidative Damage of DNA as Early Marker of Alzheimer's Disease.International journal of molecular sciences · 2019
    Trial
  2. Anti-Inflammatory and Antimicrobial Activities of Extracts Developed fromInternational journal of molecular sciences · 2026
    Article
  3. Molecules (Basel, Switzerland) · 2023
    Article
  4. Article
  5. The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. HFrontiers in pharmacology · 2017
    Review
  12. Article
  13. Nitric oxide in liver diseases.Trends in pharmacological sciences · 2015
    Review
  14. Reactive nitrogen species in cellular signaling.Experimental biology and medicine (Maywood, N.J.) · 2015
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

María C FrancoBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA.
Alvaro G Estévez
University of Central Florida · US

Funding

Peroxynitrite, nitrotyrosine and HSP90 in neuronal deathR01NS036761 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI ESTEVEZ, ALVARO G. · 1998 to 2014
$3.4M
NINDS NIH HHS NS36761NINDS NIH HHS R01 NS036761
6 · The paper itself

Abstract

Nitrotyrosine is used as a marker for the production of peroxynitrite and other reactive nitrogen species. For over 20 years the presence of nitrotyrosine was associated with cell death in multiple pathologies. Filling the gap between correlation and causality has proven to be a difficult task. Here, we discuss the evidence supporting tyrosine nitration as a specific posttranslational modification participating in the induction of cell death signaling pathways.

Indexed as

Cell DeathAnimalsHSP90 Heat-Shock ProteinsHumansInflammationPeroxynitrous AcidReactive Nitrogen SpeciesSignal TransductionSuperoxide DismutaseTyrosine3-nitrotyrosineHSP90 Heat-Shock ProteinsPeroxynitrous AcidReactive Nitrogen SpeciesSuperoxide DismutaseTyrosine

Identifiers

PMID24947321
PMCPMC11113622
OpenAlexW2053636385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.