ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Self-organized ventilation defects in asthma: insights and open-source implementation of the Venegas-Winkler model.Royal Society open science · 2026Article
- Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma.Annals of translational medicine · 2022Article
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.Materials (Basel, Switzerland) · 2021Article
- Pharmacological ablation of the airway smooth muscle layer-Mathematical predictions of functional improvement in asthma.Physiological reports · 2020Article
- N-Phase Local Expansion Ratio for Characterizing Out-of-Phase Lung Ventilation.IEEE transactions on medical imaging · 2020Article
- Reactance and elastance as measures of small airways response to bronchodilator in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The spatial pattern of methacholine bronchoconstriction recurs when supine independently of posture during provocation but does not recur between postures.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Spatial persistence of reduced specific ventilation following methacholine challenge in the healthy human lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- A Distribution-Moment Approximation for Coupled Dynamics of the Airway Wall and Airway Smooth Muscle.Biophysical journal · 2018Article
- The role of heterogeneity in asthma: a structure-to-function perspective.Clinical and translational medicine · 2017Review
- Measurement of intraindividual airway tone heterogeneity and its importance in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Hyperpolarized 3He magnetic resonance imaging ventilation defects in asthma: relationship to airway mechanics.Physiological reports · 2016Article
- Article
- Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Asymmetry and heterogeneity in the branching of the human bronchial tree are well documented, but their effects on bronchoconstriction and ventilation distribution in asthma are unclear. In a series of seminal studies, Venegas et al. have shown that bronchoconstriction may lead to self-organized patterns of patchy ventilation in a computational model that could explain areas of poor ventilation [ventilation defects (VDefs)] observed in positron emission tomography images during induced bronchoconstriction. To investigate effects of anatomic asymmetry on the emergence of VDefs we used the symmetric tree computational model that Venegas and Winkler developed using different trees, including an anatomic human airway tree provided by M. Tawhai (University of Auckland), a symmetric tree, and three trees with intermediate asymmetry (Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Nature 434: 777-782, 2005 and Winkler T, Venegas JG. J Appl Physiol 103: 655-663, 2007). Ventilation patterns, lung resistance (RL), lung elastance (EL), and the entropy of the ventilation distribution were compared at different levels of airway smooth muscle activation. We found VDefs emerging in both symmetric and asymmetric trees, but VDef locations were largely persistent in asymmetric trees, and bronchoconstriction reached steady state sooner than in a symmetric tree. Interestingly, bronchoconstriction in the asymmetric tree resulted in lower RL (∼%50) and greater EL (∼%25). We found that VDefs were universally caused by airway instability, but asymmetry in airway branching led to local triggers for the self-organized patchiness in ventilation and resulted in persistent locations of VDefs. These findings help to explain the emergence and the persistence in location of VDefs found in imaging studies.
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